naa a22 4500 510735460 CHVBK 20180411083008.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11904-013-0182-8 doi (NATIONALLICENCE)springer-10.1007/s11904-013-0182-8 Treatment of Genotype 1 HCV Infection in the HIV Coinfected Patient in 2014 [Elektronische Daten] [Cody Chastain, Susanna Naggie] Hepatitis C (HCV) coinfection is the leading cause of liver-related morbidity and is a leading cause of mortality in human immunodeficiency virus (HIV)-infected individuals in the antiretroviral therapy era. Direct-acting antiviral (DAA) therapies are transforming how HCV is treated with significant improvements in efficacy and tolerability. In this article, DAA agents expected to be available in 2014 are reviewed, including telaprevir, boceprevir, sofosbuvir, simeprevir, faldaprevir, and daclatasvir. Available data regarding clinical efficacy, adverse effects, and drug interactions in HIV-HCV coinfection are discussed. The management of adverse effects of HCV therapy and treatment considerations in patients with cirrhosis are also reviewed. Springer Science+Business Media New York, 2013 Hepatitis C nationallicence HIV nationallicence HIV-HCV coinfection nationallicence Telaprevir nationallicence Boceprevir nationallicence Sofosbuvir nationallicence Simeprevir nationallicence Faldaprevir nationallicence Daclatasvir nationallicence Chastain Cody Division of Infectious Diseases, Vanderbilt University Medical Center, A-2200 MCN, 1161 21st Avenue, 37232-2582, Nashville, TN, USA aut Naggie Susanna Division of Infectious Diseases, Duke Clinical Research Institute, DUMC 102359, 27710, Durham, NC, USA aut Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/4(2013-12-01), 408-419 1548-3568 10:4<408 2013 10 11904 https://doi.org/10.1007/s11904-013-0182-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-013-0182-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chastain Cody Division of Infectious Diseases, Vanderbilt University Medical Center, A-2200 MCN, 1161 21st Avenue, 37232-2582, Nashville, TN, USA aut NATIONALLICENCE 700 1- Naggie Susanna Division of Infectious Diseases, Duke Clinical Research Institute, DUMC 102359, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/4(2013-12-01), 408-419 1548-3568 10:4<408 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer