naa a22 4500 510735592 CHVBK 20180411083008.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11904-013-0157-9 doi (NATIONALLICENCE)springer-10.1007/s11904-013-0157-9 Use of Antiretrovirals for HIV Prevention: What Do We Know and What Don't We Know? [Elektronische Daten] [Jared Baeten, Robert Grant] Pre-exposure prophylaxis (PrEP), in which HIV uninfected persons with ongoing HIV risk use antiretroviral medications as chemoprophylaxis against sexual HIV acquisition, is a promising new HIV prevention strategy. Proof-of-concept that PrEP, as oral or vaginal topical tenofovir-based products, protects against sexual HIV acquisition has been demonstrated in clinical trials conducted among men who have sex with men and heterosexual men and women. The degree of HIV protection in these trials was strongly related to the level of adherence to PrEP. Many questions are yet unanswered - including how to motivate uptake of and sustain adherence to PrEP for HIV prevention, how much PrEP use is enough to achieve HIV protection, and the potential of "next-generation” PrEP agents to improve on this effective technology. Springer Science+Business Media New York, 2013 Antiretroviral medications nationallicence Chemoprophylaxis nationallicence Global epidemic nationallicence HIV/AIDS nationallicence HIV prevention nationallicence Pre-exposure prophylaxis (PrEP) nationallicence Sexual HIV transmission nationallicence Baeten Jared Departments of Global Health, Medicine, and Epidemiology, University of Washington, 325 Ninth Avenue, Box 359927, 98104, Seattle, WA, USA aut Grant Robert Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, 94158, San Francisco, CA, USA aut Current HIV/AIDS Reports Current Science Inc. 10/2(2013-06-01), 142-151 1548-3568 10:2<142 2013 10 11904 https://doi.org/10.1007/s11904-013-0157-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-013-0157-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baeten Jared Departments of Global Health, Medicine, and Epidemiology, University of Washington, 325 Ninth Avenue, Box 359927, 98104, Seattle, WA, USA aut NATIONALLICENCE 700 1- Grant Robert Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, 94158, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/2(2013-06-01), 142-151 1548-3568 10:2<142 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer