naa a22 4500 510735614 CHVBK 20180411083008.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11904-013-0154-z doi (NATIONALLICENCE)springer-10.1007/s11904-013-0154-z Antiretroviral Drug Regimens to Prevent Mother-To-Child Transmission of HIV: A Review of Scientific, Program, and Policy Advances for Sub-Saharan Africa [Elektronische Daten] [Benjamin Chi, Jeffrey Stringer, Dhayendre Moodley] Considerable advances have been made in the effort to prevent mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods. Scientific discoveries have been rapidly translated into health policy, bolstered by substantial investment in health infrastructure capable of delivering increasingly complex services. A new scientific agenda is also emerging, one that is focused on the challenges of effective and sustainable program implementation. Finally, global campaigns to "virtually eliminate” pediatric HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and renewed political will. Each of these developments marks a major step in regional PMTCT efforts; their convergence signals a time of rapid progress in the field, characterized by an increased interdependency between clinical research, program implementation, and policy. In this review, we take stock of recent advances across each of these areas, highlighting the challenges—and opportunities—of improving health services for HIV-infected mothers and their children across the region. Springer Science+Business Media New York, 2013 Prevention of mother-to-child HIV transmission nationallicence PMTCT nationallicence HIV nationallicence Antiretroviral prophylaxis nationallicence Sub-Saharan Africa nationallicence Global epidemic nationallicence Chi Benjamin Centre for Infectious Disease Research in Zambia (CIDRZ), Plot 1275 Lubutu Road, P.O. Box 34681, Lusaka, Zambia aut Stringer Jeffrey Centre for Infectious Disease Research in Zambia (CIDRZ), Plot 1275 Lubutu Road, P.O. Box 34681, Lusaka, Zambia aut Moodley Dhayendre Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa aut Current HIV/AIDS Reports Current Science Inc. 10/2(2013-06-01), 124-133 1548-3568 10:2<124 2013 10 11904 https://doi.org/10.1007/s11904-013-0154-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-013-0154-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chi Benjamin Centre for Infectious Disease Research in Zambia (CIDRZ), Plot 1275 Lubutu Road, P.O. Box 34681, Lusaka, Zambia aut NATIONALLICENCE 700 1- Stringer Jeffrey Centre for Infectious Disease Research in Zambia (CIDRZ), Plot 1275 Lubutu Road, P.O. Box 34681, Lusaka, Zambia aut NATIONALLICENCE 700 1- Moodley Dhayendre Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/2(2013-06-01), 124-133 1548-3568 10:2<124 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer