naa a22 4500 51073832X CHVBK 20180411083019.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12127-013-0119-3 doi (NATIONALLICENCE)springer-10.1007/s12127-013-0119-3 Enhancing sensitivity of ion mobility spectrometry determination of aldehydes by in situ gas phase derivatization with dibutylamine [Elektronische Daten] [Hamideh Kalhor, Naader Alizadeh] A simple and fast method for the detection of aldehydes by headspace solid-phase microextraction (HS-SPME) based on nanostructure polypyrrole film coupled to ion mobility spectrometery (IMS) is described. The detection of aldehydes (pentanal, hexanal and heptanal) has been successfully accomplished using in situ chemical derivatization with dibutylamine as the derivatization reagent and IMS. The simultaneous and rapid detection of aldehydes is important, since elevated level of aldehydes is considered as the biomarker of different diseases. The highlight of this method was that it involved an amine nucleophilic addition reaction (which was often considered as Mannich reaction) in gas phase for enhancing IMS sensitivity of aldehydes. Dibutylamine was used as the derivatization reagent driven into the cell by using a syringe pump. The calibration graphs were linear in the range of 2.0-50.0μg mL−1 with R 2 ≥ 0.99 in aqueous solutions and limit of detections were determined ≤ 1.8μg mL−1. The RSD% values of the aldehydes determination was ≤ 8%. Here we have demonstrated that other amine types (butylamine and tributylamine) can derivatize aldehydes and significantly improve the IMS sensitivity of tagged analytes. However, IMS spectrum is complicated by presence of the different product ions in the process. Springer-Verlag Berlin Heidelberg, 2013 Enhancing sensitivity nationallicence Ion mobility spectrometery nationallicence Aldehyde nationallicence HS-SPME nationallicence Polypyrrole nationallicence Nanostructure nationallicence Kalhor Hamideh Department of Chemistry, Faculty of Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran aut Alizadeh Naader Department of Chemistry, Faculty of Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran aut International Journal for Ion Mobility Spectrometry Springer Berlin Heidelberg 16/3(2013-09-01), 199-205 1435-6163 16:3<199 2013 16 12127 https://doi.org/10.1007/s12127-013-0119-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12127-013-0119-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kalhor Hamideh Department of Chemistry, Faculty of Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran aut NATIONALLICENCE 700 1- Alizadeh Naader Department of Chemistry, Faculty of Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran aut NATIONALLICENCE 773 0- International Journal for Ion Mobility Spectrometry Springer Berlin Heidelberg 16/3(2013-09-01), 199-205 1435-6163 16:3<199 2013 16 12127 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer