naa a22 4500 510738354 CHVBK 20180411083019.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12127-013-0136-2 doi (NATIONALLICENCE)springer-10.1007/s12127-013-0136-2 Speciation effects of solvent chemistry on the analysis of drugs and explosives by electrospray ion mobility mass spectrometry [Elektronische Daten] [Howard Holness, Jose Almirall] The present work highlights the effect that solvent chemistry has on analytes being detected when utilizing electrospray ionization in ion mobility mass spectrometers. Various studies were conducted involving both positive and negative mode ionization. The enhancements observed by utilizing different levels of acid modifiers as well as the different ionic species of analytes being formed and detected are presented. The makeup of the electrospray solvent determined whether the ionic species would be protonated, sodium adducted, ammonium adducted, proton abstracted or chlorinated. Addition of solvent modifiers such as acids in the positive mode, and organic halides in the negative mode improved signal strength of analytes as well as improved spray characteristics that also decreased signal variability. The ability to perform simultaneous ionization of complex mixtures was also demonstrated through the use of solvent modifiers thereby allowing electrospray ionization ion mobility mass spectrometry the ability to simultaneously analyze complicated mixtures very quickly (millisecond separations). Springer-Verlag Berlin Heidelberg, 2013 Ion mobility nationallicence Mass spectrometry nationallicence Electrospray nationallicence Explosives nationallicence Drugs nationallicence Solvent chemistry nationallicence Holness Howard Department of Chemistry and Biochemistry and International Forensic Research Institute, Florida International University, 11200 SW 8th Street, 33199, Miami, FL, USA aut Almirall Jose Department of Chemistry and Biochemistry and International Forensic Research Institute, Florida International University, 11200 SW 8th Street, 33199, Miami, FL, USA aut International Journal for Ion Mobility Spectrometry Springer Berlin Heidelberg 16/3(2013-09-01), 237-246 1435-6163 16:3<237 2013 16 12127 https://doi.org/10.1007/s12127-013-0136-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12127-013-0136-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holness Howard Department of Chemistry and Biochemistry and International Forensic Research Institute, Florida International University, 11200 SW 8th Street, 33199, Miami, FL, USA aut NATIONALLICENCE 700 1- Almirall Jose Department of Chemistry and Biochemistry and International Forensic Research Institute, Florida International University, 11200 SW 8th Street, 33199, Miami, FL, USA aut NATIONALLICENCE 773 0- International Journal for Ion Mobility Spectrometry Springer Berlin Heidelberg 16/3(2013-09-01), 237-246 1435-6163 16:3<237 2013 16 12127 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer