naa a22 4500 510738397 CHVBK 20180411083019.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12127-013-0139-z doi (NATIONALLICENCE)springer-10.1007/s12127-013-0139-z Corona discharge ion mobility spectrometry for the determination of theophylline and guaifenesin in human serum [Elektronische Daten] [A. Sheibani, S. Masoumi, S. Partovi] This paper describes the determination of theophylline and guaifenesin in human serum using ion mobility spectrometry with positive corona discharge as source ionization. The optimization of parameters that could influence ion mobility spectrometry was investigated. Under optimum conditions (Temperature; injection: 220 and oven: 175°C, Flow rate; carrier: 300 and drift: 600mLmin−1, Voltage; corona: 2300 and drift: 7000V, pulse width: 100μs), calibration curves were linear in the ranges of 2 to120 and 6 to 120ng for theophylline and guaifenesin, respectively. The relative standard deviation (n = 10) was below 12%. The detection limits were found to be 0.1ng for theophylline and 0.5ng for guaifenesin. The recovery results for the theophylline and guaifenesin determination in human serum was about 80% that indicate the proposed method can be applied for the two drugs analysis in real sample. Furthermore, the proposed method has been evaluated in the simultaneous determination of the two drugs. Springer-Verlag Berlin Heidelberg, 2013 Ion mobility spectrometry (IMS) nationallicence Theophylline nationallicence Guaifenesin nationallicence Human serum nationallicence Sheibani A. Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran aut Masoumi S. Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran aut Partovi S. Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran aut International Journal for Ion Mobility Spectrometry Springer Berlin Heidelberg 16/4(2013-12-01), 259-263 1435-6163 16:4<259 2013 16 12127 https://doi.org/10.1007/s12127-013-0139-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12127-013-0139-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheibani A. Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran aut NATIONALLICENCE 700 1- Masoumi S. Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran aut NATIONALLICENCE 700 1- Partovi S. Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran aut NATIONALLICENCE 773 0- International Journal for Ion Mobility Spectrometry Springer Berlin Heidelberg 16/4(2013-12-01), 259-263 1435-6163 16:4<259 2013 16 12127 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer