naa a22 4500 510738516 CHVBK 20180411083019.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12127-013-0131-7 doi (NATIONALLICENCE)springer-10.1007/s12127-013-0131-7 The potential for clinical applications using a new ionization method combined with ion mobility spectrometry-mass spectrometry [Elektronische Daten] [Ellen Inutan, James Wager-Miller, Srinivas Narayan, Ken Mackie, Sarah Trimpin] Recently discovered ionization methods for use in mass spectrometry (MS), are widely applicable to biological materials, robust, and easy to automate. Among these, matrix assisted ionization vacuum (MAIV) is astonishing in that ionization of low and high-mass compounds are converted to gas-phase ions with charge states similar to electrospray ionization simply by exposing a matrix:analyte mixture to the vacuum of a mass spectrometer. Using the matrix compound, 3-nitrobenzonitrile, abundant ions are produced at room temperature without the need of high voltage or a laser. Here we discuss chemical analyses advances using MAIV combined with ion mobility spectrometry (IMS) real time separation, high resolution MS, and mass selected and non-mass selected MS/MS providing rapid analyte characterization. Drugs, their metabolites, lipids, peptides, and proteins can be ionized simultaneously from a variety of different biological matrixes such as urine, plasma, whole blood, and tissue. These complex mixtures are best characterized using a separation step, which is obtained nearly instantaneously with IMS, and together with direct ionization and MS or MS/MS provides a fast analysis method that has considerable potential for non-targeted clinical analyses. Springer-Verlag Berlin Heidelberg, 2013 Ion mobility spectrometry mass spectrometry nationallicence Matrix assisted ionization vacuum nationallicence Clinical mass spectrometry nationallicence Drugs nationallicence Proteins nationallicence Plasma nationallicence Blood nationallicence Tissue nationallicence Nested data nationallicence Non-selected MS/MS nationallicence Non-targeted nationallicence Profiling nationallicence Inutan Ellen Department of Chemistry, Wayne State University, 48202, Detroit, MI, USA aut Wager-Miller James Gill Center for Biomolecular Science, Indiana University, 47405, Bloomington, IN, USA aut Narayan Srinivas Detroit Medical Center University Laboratories, 48219, Detroit, MI, USA aut Mackie Ken Gill Center for Biomolecular Science, Indiana University, 47405, Bloomington, IN, USA aut Trimpin Sarah Department of Chemistry, Wayne State University, 48202, Detroit, MI, USA aut International Journal for Ion Mobility Spectrometry Springer-Verlag 16/2(2013-06-01), 145-159 1435-6163 16:2<145 2013 16 12127 https://doi.org/10.1007/s12127-013-0131-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12127-013-0131-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inutan Ellen Department of Chemistry, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Wager-Miller James Gill Center for Biomolecular Science, Indiana University, 47405, Bloomington, IN, USA aut NATIONALLICENCE 700 1- Narayan Srinivas Detroit Medical Center University Laboratories, 48219, Detroit, MI, USA aut NATIONALLICENCE 700 1- Mackie Ken Gill Center for Biomolecular Science, Indiana University, 47405, Bloomington, IN, USA aut NATIONALLICENCE 700 1- Trimpin Sarah Department of Chemistry, Wayne State University, 48202, Detroit, MI, USA aut NATIONALLICENCE 773 0- International Journal for Ion Mobility Spectrometry Springer-Verlag 16/2(2013-06-01), 145-159 1435-6163 16:2<145 2013 16 12127 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer