naa a22 4500 51073894X CHVBK 20180411083021.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s12015-011-9345-4 doi (NATIONALLICENCE)springer-10.1007/s12015-011-9345-4 Multipotent Mesenchymal Stromal Cell Therapy and Risk of Malignancies [Elektronische Daten] [Federica Casiraghi, Giuseppe Remuzzi, Mauro Abbate, Norberto Perico] Cell therapy with Multipotent Mesenchymal Stromal Cells (MSC) holds enormous promise for the treatment of a large number of degenerative and immune/inflammatory diseases. Their multilineage differentiation potential, immunoprivilege and capacity of promoting recovery of damaged tissues coupled with anti-inflammatory and immunosuppressive properties are the focus of a multitude of clinical studies currently underway. The recognized clinical potential of MSC repairing/immunomodulatory effects now encompasses graft-versus-host disease, hematologic malignancies, cardiovascular diseases, neurologic and inherited diseases, autoimmune diseases, organ transplantation, refractory wounds, and bone/cartilage defects among others. However, it has been suggested that both the need of extensive ex vivo culture for MSC clinical use, and their proangiogenic, anti-apoptotic and immunomodulatory properties may act together as tumor promoters, raising significant safety concerns. This paper will review the available data on in vitro MSC maldifferentiation and the ability of MSC to sustain tumor growth in vivo, with the aim to clarify whether MSC-based therapeutic approaches may carry actual risk of malignancies. Springer Science+Business Media, LLC, 2012 Multipotent mesenchymal stromal cells nationallicence Malignant maldifferentiation nationallicence Cancer nationallicence Tumor nationallicence Safety nationallicence Casiraghi Federica Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut Remuzzi Giuseppe Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut Abbate Mauro Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut Perico Norberto Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut Stem Cell Reviews and Reports Humana Press Inc 9/1(2013-02-01), 65-79 1550-8943 9:1<65 2013 9 12015 https://doi.org/10.1007/s12015-011-9345-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-011-9345-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Casiraghi Federica Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut NATIONALLICENCE 700 1- Remuzzi Giuseppe Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut NATIONALLICENCE 700 1- Abbate Mauro Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut NATIONALLICENCE 700 1- Perico Norberto Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi”, Department of Immunology and Transplantation, Ospedali Riuniti - Mario Negri Institute for Pharmacological Research, Bergamo, Italy aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/1(2013-02-01), 65-79 1550-8943 9:1<65 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer