naa a22 4500 510739091 CHVBK 20180411083021.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12015-013-9460-5 doi (NATIONALLICENCE)springer-10.1007/s12015-013-9460-5 Cell Cycle Regulation During Neurogenesis in the Embryonic and Adult Brain [Elektronische Daten] [Arquimedes Cheffer, Attila Tárnok, Henning Ulrich] Throughout the development of the central nervous system, neural crest cells and the primary neural stem cells originate several non-neuronal and neuronal cell types. Undifferentiated stem cells exist in the adult brain, mainly in the dentate gyrus of the hippocampus and in the subventricular zone of the lateral ventricles, and can produce new neurons, participating in brain plasticity and tissue regeneration. Neurogenesis in the embryonic and adult brain occurs under the control of intrinsic and extrinsic factors. However, the mechanisms, by which cell cycle components control neural stem cell proliferation and consequently neurogenesis, still lack further investigation. We discuss here recent knowledge obtained on cell cycle components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain. Springer Science+Business Media New York, 2013 Cell cycle nationallicence Neural stem cells nationallicence Proliferation nationallicence Neurogenesis nationallicence Embryonic and adult brain nationallicence Cheffer Arquimedes Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil aut Tárnok Attila Department of Pediatric Cardiology, Heart Centre, and Translational Center of Regenerative, Medicine Leipzig, TRM, Medical Faculty, University Leipzig, Leipzig, Germany aut Ulrich Henning Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil aut Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/6(2013-12-01), 794-805 1550-8943 9:6<794 2013 9 12015 https://doi.org/10.1007/s12015-013-9460-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9460-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheffer Arquimedes Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Tárnok Attila Department of Pediatric Cardiology, Heart Centre, and Translational Center of Regenerative, Medicine Leipzig, TRM, Medical Faculty, University Leipzig, Leipzig, Germany aut NATIONALLICENCE 700 1- Ulrich Henning Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/6(2013-12-01), 794-805 1550-8943 9:6<794 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer