naa a22 4500 510739105 CHVBK 20180411083021.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12015-013-9469-9 doi (NATIONALLICENCE)springer-10.1007/s12015-013-9469-9 Abdelalim Essam Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, 41522, Ismailia, Egypt aut Molecular Mechanisms Controlling the Cell Cycle in Embryonic Stem Cells [Elektronische Daten] [Essam Abdelalim] Embryonic stem (ES) cells are originated from the inner cell mass of a blastocyst stage embryo. They can proliferate indefinitely, maintain an undifferentiated state (self-renewal), and differentiate into any cell type (pluripotency). ES cells have an unusual cell cycle structure, consists mainly of S phase cells, a short G1 phase and absence of G1/S checkpoint. Cell division and cell cycle progression are controlled by mechanisms ensuring the accurate transmission of genetic information from generation to generation. Therefore, control of cell cycle is a complicated process, involving several signaling pathways. Although great progress has been made on the molecular mechanisms involved in the regulation of ES cell cycle, many regulatory mechanisms remain unknown. This review summarizes the current knowledge about the molecular mechanisms regulating the cell cycle of ES cells and describes the relationship existing between cell cycle progression and the self-renewal. Springer Science+Business Media New York, 2013 ES cells nationallicence Self-renewal nationallicence G1 phase nationallicence Pathway nationallicence Pluripotency nationallicence Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/6(2013-12-01), 764-773 1550-8943 9:6<764 2013 9 12015 https://doi.org/10.1007/s12015-013-9469-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9469-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Abdelalim Essam Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, 41522, Ismailia, Egypt aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/6(2013-12-01), 764-773 1550-8943 9:6<764 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer