naa a22 4500 510739156 CHVBK 20180411083021.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12015-012-9421-4 doi (NATIONALLICENCE)springer-10.1007/s12015-012-9421-4 Cardiac Stem Cells and their Roles in Myocardial Infarction [Elektronische Daten] [Jingying Hou, Lingyun Wang, Jieyu Jiang, Changqing Zhou, Tianzhu Guo, Shaoxin Zheng, Tong Wang] Myocardial infarction leads to loss of cardiomyocytes, scar formation, ventricular remodeling and eventually deterioration of heart function. Over the past decade, stem cell therapy has emerged as a novel strategy for patients with ischemic heart disease and its beneficial effects have been demonstrated by substantial preclinical and clinical studies. Efficacy of several types of stem cells in the therapy of cardiovascular diseases has already been evaluated. However, repair of injured myocardium through stem cell transplantation is restricted by critical safety issues and ethic concerns. Recently, the discovery of cardiac stem cells (CSCs) that reside in the heart itself brings new prospects for myocardial regeneration and reconstitution of cardiac tissues. CSCs are positive for various stem cell markers and have the potential of self-renewal and multilineage differentiation. They play a pivotal role in the maintenance of heart homeostasis and cardiac repair. Elucidation of their biological characteristics and functions they exert in myocardial infarction are very crucial to further investigations on them. This review will focus on the field of cardiac stem cells and discuss technical and practical issues that may involve in their clinical applications in myocardial infarction. Springer Science+Business Media New York, 2012 Cardiac stem cells nationallicence Myocardial infarction nationallicence Cell therapy nationallicence Myocardial regeneration nationallicence Cardiac repair nationallicence CSCs : Cardiac stem cells nationallicence MI : Myocardial infarction nationallicence CPCs : Cardiac progenitor cells nationallicence ESCs : Embryonic stem cells nationallicence BMSCs : Bone marrow stem cells nationallicence iPSCs : Induced pluripotent stem cells nationallicence EPCs : Embryo progenitor cells nationallicence BMPCs : Bone marrow progenitors cells nationallicence SP : Side population nationallicence LV : Left ventricular nationallicence mCSCs : Myogenic CSCs nationallicence vCSCs : Vasculogenic CSCs nationallicence IGF-1 : Insulin-like growth factor 1 nationallicence HGF : Hepatocyte growth factor nationallicence SDF-1 : Stromal cell-derived factor-1 nationallicence VEGF : Vascular endothelial growth factor nationallicence TGF-β : Transforming growth factor beta nationallicence BMP : Bone morphogenetic protein nationallicence Hou Jingying Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut Wang Lingyun Department of Gastroenterology, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China aut Jiang Jieyu Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut Zhou Changqing Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut Guo Tianzhu Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut Zheng Shaoxin Department of Cardiology, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China aut Wang Tong Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut Stem Cell Reviews and Reports Humana Press Inc 9/3(2013-06-01), 326-338 1550-8943 9:3<326 2013 9 12015 https://doi.org/10.1007/s12015-012-9421-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9421-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hou Jingying Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Wang Lingyun Department of Gastroenterology, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Jiang Jieyu Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Zhou Changqing Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Guo Tianzhu Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Zheng Shaoxin Department of Cardiology, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China aut NATIONALLICENCE 700 1- Wang Tong Department of Emergency, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 Yanjiang Xi Road, Zip code: 510120, Guangzhou, Guangdong, China aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/3(2013-06-01), 326-338 1550-8943 9:3<326 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer