naa a22 4500 510739199 CHVBK 20180411083022.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12015-012-9353-z doi (NATIONALLICENCE)springer-10.1007/s12015-012-9353-z Cardiac Cell Therapy: Boosting Mesenchymal Stem Cells Effects [Elektronische Daten] [E. Samper, A. Diez-Juan, J. Montero, P. Sepúlveda] Acute myocardial infarction is a major problem of world public health and available treatments have limited efficacy. Cardiac cell therapy is a new therapeutic strategy focused on regeneration and repair of the injured cardiac muscle. Among different cell types used, mesenchymal stem cells (MSC) have been widely tested in preclinical studies and several clinical trials have evaluated their clinical efficacy in myocardial infarction. However, the beneficial effects of MSC in humans are limited due to poor engraftment and survival of these cells, therefore ways to overcome these obstacles should improve efficacy. Different strategies have been used, such as genetically modifying MSC, or preconditioning the cells with factors that potentiate their survival and therapeutic mechanisms. In this review we compile the most relevant approaches used to improve MSC therapeutic capacity and to understand the molecular mechanisms involved in MSC mediated cardiac repair. Springer Science+Business Media, LLC, 2012 Myocardial infarction nationallicence Cardiac regeneration nationallicence Cell therapy nationallicence Mesenchymal stem cells nationallicence Genetic engineering nationallicence Adult stem cells nationallicence Samper E. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain aut Diez-Juan A. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Centro Investigación Príncipe Felipe, Valencia, Spain aut Montero J. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain aut Sepúlveda P. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain aut Stem Cell Reviews and Reports Humana Press Inc 9/3(2013-06-01), 266-280 1550-8943 9:3<266 2013 9 12015 https://doi.org/10.1007/s12015-012-9353-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9353-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Samper E. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain aut NATIONALLICENCE 700 1- Diez-Juan A. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Centro Investigación Príncipe Felipe, Valencia, Spain aut NATIONALLICENCE 700 1- Montero J. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain aut NATIONALLICENCE 700 1- Sepúlveda P. Mixt Unit for cardiovascular repair IIS La Fe-CIPF, Fundación Hospital La Fe, Valencia, Spain aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/3(2013-06-01), 266-280 1550-8943 9:3<266 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer