naa a22 4500 510739245 CHVBK 20180411083022.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12015-012-9398-z doi (NATIONALLICENCE)springer-10.1007/s12015-012-9398-z Epigenetic Programming and Risk: The Birthplace of Cardiovascular Disease? [Elektronische Daten] [Maria Vinci, Gianluca Polvani, Maurizio Pesce] Epigenetics, through control of gene expression circuitries, plays important roles in various physiological processes such as stem cell differentiation and self renewal. This occurs during embryonic development, in different tissues, and in response to environmental stimuli. The language of epigenetic program is based on specific covalent modifications of DNA and chromatin. Thus, in addition to the individual identity, encoded by sequence of the four bases of the DNA, there is a cell type identity characterized by its positioning in the epigenetic "landscape”. Aberrant changes in epigenetic marks induced by environmental cues may contribute to the development of abnormal phenotypes associated with different human diseases such as cancer, neurological disorders and inflammation. Most of the epigenetic studies have focused on embryonic development and cancer biology, while little has been done to explore the role of epigenetic mechanisms in the pathogenesis of cardiovascular disease. This review highlights our current knowledge of epigenetic gene regulation and the evidence that chromatin remodeling and histone modifications play key roles in the pathogenesis of cardiovascular disease through (re)programming of cardiovascular (stem) cells commitment, identity and function. Springer Science+Business Media, LLC, 2012 Cardiovascular disease nationallicence Epigenetic programming nationallicence Metabolic memory nationallicence Developmental plasticity nationallicence Differentiation nationallicence Stem cells nationallicence Nutriepigenomics nationallicence Vinci Maria Laboratory of Cardiovascular Tissue Engineering, Monzino Cardiology Center, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Polvani Gianluca Department of Cardiovascular Science, Milan University, Milan, Italy aut Pesce Maurizio Laboratory of Cardiovascular Tissue Engineering, Monzino Cardiology Center, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Stem Cell Reviews and Reports Humana Press Inc 9/3(2013-06-01), 241-253 1550-8943 9:3<241 2013 9 12015 https://doi.org/10.1007/s12015-012-9398-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9398-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vinci Maria Laboratory of Cardiovascular Tissue Engineering, Monzino Cardiology Center, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Polvani Gianluca Department of Cardiovascular Science, Milan University, Milan, Italy aut NATIONALLICENCE 700 1- Pesce Maurizio Laboratory of Cardiovascular Tissue Engineering, Monzino Cardiology Center, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/3(2013-06-01), 241-253 1550-8943 9:3<241 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer