naa a22 4500 510739296 CHVBK 20180411083022.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12015-012-9369-4 doi (NATIONALLICENCE)springer-10.1007/s12015-012-9369-4 Induced Pluripotent Stem Cell Technology and Direct Conversion: New Possibilities to Study and Treat Parkinson's Disease [Elektronische Daten] [Reinhard Roessler, Erik Boddeke, Sjef Copray] Recent developments in in vitro disease modeling and regenerative medicine have placed induced pluripotent stem cells (iPSCs) in the center of attention as a unique source to study Parkinson's disease. After only 5years of intensive research, human iPSCs can be generated without viral integration and under xeno-free conditions. This, combined with increasingly sophisticated methods to differentiate iPSCs into functional dopaminergic (DA) neurons, led us to recapitulate the most important findings concerning the use of iPSC technology as a prospective tool to treat symptoms of Parkinson's disease as well as to obtain insight in disease related cell pathogenesis. Moreover, we touch upon some of the latest discoveries in which patient-derived autologous DA neurons come into even more direct reach thanks to a method that allows transdifferentiation of fibroblasts into DA neurons. The Author(s), 2012 Induced pluripotent stem cells nationallicence Parkinson's disease nationallicence Dopaminergic neurons nationallicence In vitro disease modeling nationallicence Cell based therapy nationallicence Transdifferentiation nationallicence Roessler Reinhard Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, A.Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Boddeke Erik Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, A.Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Copray Sjef Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, A.Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/4(2013-08-01), 505-513 1550-8943 9:4<505 2013 9 12015 https://doi.org/10.1007/s12015-012-9369-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9369-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roessler Reinhard Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, A.Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Boddeke Erik Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, A.Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Copray Sjef Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, A.Deusinglaan 1, 9713 AV, Groningen, The Netherlands aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/4(2013-08-01), 505-513 1550-8943 9:4<505 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer