naa a22 4500 510739318 CHVBK 20180411083022.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12015-012-9388-1 doi (NATIONALLICENCE)springer-10.1007/s12015-012-9388-1 Mesodermal and Hematopoietic Differentiation from ES and iPS Cells [Elektronische Daten] [Tomoko Inoue-Yokoo, Kenzaburo Tani, Daisuke Sugiyama] Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells. Springer Science+Business Media, LLC, 2012 Mesoderm induction nationallicence Hematopoietic cell differentiation nationallicence ES cell nationallicence iPS cell nationallicence ES : Embryonic stem nationallicence iPS : Induced pluripotent stem nationallicence HSC : Hematopoietic stem cell nationallicence HPC : Hematopoietic progenitor cell nationallicence HC : Hematopoietic cell nationallicence Inoue-Yokoo Tomoko Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, 812-8582, Fukuoka, Japan aut Tani Kenzaburo Department of Medical Genomics, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan aut Sugiyama Daisuke Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, 812-8582, Fukuoka, Japan aut Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/4(2013-08-01), 422-434 1550-8943 9:4<422 2013 9 12015 https://doi.org/10.1007/s12015-012-9388-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9388-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue-Yokoo Tomoko Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tani Kenzaburo Department of Medical Genomics, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sugiyama Daisuke Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/4(2013-08-01), 422-434 1550-8943 9:4<422 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer