naa a22 4500 510739350 CHVBK 20180411083022.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s12015-013-9459-y doi (NATIONALLICENCE)springer-10.1007/s12015-013-9459-y Turksen Kursad Regenerative Medicine Program, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, K1H 8L6, Ottawa, ON, Canada aut End of Inevitability: Programming and Reprogramming [Elektronische Daten] [Kursad Turksen] Stem cell commitment and differentiation leading to functional cell types and organs has generally been considered unidirectional and deterministic. Starting first with a landmark study 50years ago, and now with more recent observations, this paradigm has been challenged, necessitating a rethink of what constitutes both programming and reprogramming processes, and how we can use this new understanding for new approaches to drug discovery and regenerative medicine. Springer Science+Business Media New York, 2013 Programming nationallicence Reprogramming nationallicence Induced pluripotent stem cells nationallicence Epigenetic nationallicence Differentiation nationallicence Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/4(2013-08-01), 385-387 1550-8943 9:4<385 2013 9 12015 https://doi.org/10.1007/s12015-013-9459-y text/html Onlinezugriff via DOI 1 editorial jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9459-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Turksen Kursad Regenerative Medicine Program, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, 501 Smyth Road, K1H 8L6, Ottawa, ON, Canada aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/4(2013-08-01), 385-387 1550-8943 9:4<385 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer