naa a22 4500 510739482 CHVBK 20180411083023.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12015-013-9437-4 doi (NATIONALLICENCE)springer-10.1007/s12015-013-9437-4 Stem Cells in Liver Regeneration and Their Potential Clinical Applications [Elektronische Daten] [Ioannis Drosos, George Kolios] Stem cells constitute a population of "primitive cells” with the ability to divide indefinitely and give rise to specialized cells under special conditions. Because of these two characteristics they have received particular attention in recent decades. These cells are the primarily responsible factors for the regeneration of tissues and organs and for the healing of lesions, a feature that makes them a central key in the development of cell-based medicine, called Regenerative Medicine. The idea of wound and organ repair and body regeneration is as old as the mankind, reflecting the human desire for inhibiting aging and immortality and it is first described in the ancient Greek myth of Prometheus. It is of interest that the myth refers to liver, an organ with remarkable regenerative ability after loss of mass and function caused by liver injury or surgical resection. Over the last decade there has been an important progress in understanding liver physiology and the mechanisms underlying hepatic development and regeneration. As liver transplantation, despite its difficulties, remains the only effective therapy for advanced liver disease so far, scientific interest has nowadays been orientated towards Regenerative Medicine and the use of stem cells to repair damaged liver. This review is focused on the available literature concerning the role of stem cells in liver regeneration. It summarizes the results of studies concerning endogenous liver regeneration and stem cell experimental protocols. Moreover, this review discusses the clinical studies that have been conducted in humans so far. Springer Science+Business Media New York, 2013 Stem cells nationallicence Hepatocytes nationallicence Liver regeneration nationallicence Regenerative medicine nationallicence 2-AAF : 2-acetylaminofluorene nationallicence AFP : Alpha fetoprotein nationallicence ALB : Albumin nationallicence BM : Bone marrow nationallicence BM-MSC : Bone marrow derived mesenchymal stem cell nationallicence BM-SC : Bone marrow stem cell nationallicence CCl4 : Carbon tetrachloride nationallicence CK : Cytokeratin nationallicence EB : Embryoid body nationallicence ESC : Embryonic stem cell nationallicence FAH : Fumarylacetoacetate hydrolase nationallicence G-CSF : Granulocyte colony stimulating factor nationallicence HBV : Hepatitis B virus nationallicence HCV : Hepatitis C virus nationallicence HEV : Hepatitis E virus nationallicence hHpSCs : Human hepatic stem cells nationallicence HNF : Hepatocyte nuclear factor nationallicence HNF-3β : Hepatocyte nuclear factor 3 beta nationallicence HSC : Hematopoietic stem cell nationallicence ICG : Indocyanine green nationallicence iPSC : Induced pluripotent stem cell nationallicence LIF : Leukemia inhibiting factor nationallicence MAPC : Multipotent adult progenitor cell nationallicence MEFC : Mouse embryonic fibroblast cell nationallicence MMP : Metalloproteinase nationallicence MSC : Mesenchymal stem cell nationallicence MSC-CM : Mesenchymal stem cell conditioned medium nationallicence NTBC : 2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) nationallicence PH : Partial hepatectomy nationallicence rha-FGF : Recombinant human acidic fibroblast growth factor nationallicence rhb-FGF : Recombinant human basic fibroblast growth factor nationallicence rHGF : Recombinant hepatocyte growth factor nationallicence TTR : Transthyretin nationallicence UCB : Umbilical cord blood nationallicence UCB-HSC : Umbilical cord blood derived hematopoietic stem cell nationallicence UCB-MSC : Umbilical cord blood derived mesenchymal stem cell nationallicence uPA : Urokinase plasminogen activator nationallicence γ-GT : Gamma glutamyltransferase nationallicence Drosos Ioannis Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece aut Kolios George Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece aut Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/5(2013-10-01), 668-684 1550-8943 9:5<668 2013 9 12015 https://doi.org/10.1007/s12015-013-9437-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9437-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Drosos Ioannis Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece aut NATIONALLICENCE 700 1- Kolios George Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/5(2013-10-01), 668-684 1550-8943 9:5<668 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer