naa a22 4500 510739520 CHVBK 20180411083023.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12015-013-9445-4 doi (NATIONALLICENCE)springer-10.1007/s12015-013-9445-4 The Impact of Commercialisation on Public Perceptions of Stem Cell Research: Exploring Differences Across the Use of Induced Pluripotent Cells, Human and Animal Embryos [Elektronische Daten] [Christine Critchley, Gordana Bruce, Matthew Farrugia] The development of pluripotent cells that enable stem cell research (SCR) without destroying human embryos is now a leading priority for science. Public and political controversies associated with human embryonic SCR experienced in the recent past should be alleviated if scientists no longer need to harvest cells from human embryos. This research suggests however additional issues needing attention in order to gain the public's trust and support: the use of mouse embryos and the commercialisation of research. Using a representative sample of 2,800 Australians, and an experimental telephone survey design, this research compared levels and predictors of public support for stem cell research across three cell source conditions: human embryo (HE), mouse embryo (ME) and induced pluripotent cells (iPSCs). The results revealed that the public were significantly more likely to support research using iPSCs than HE and ME cells and public compared to private research (regardless of the cell source). There was no significant difference in support for HE compared to ME research, but the former was viewed as more likely to lead to accessible health care benefits and to be associated with more trustworthy scientists. The results of a multimediation structural equation model showed that the primary reason support for SCR significantly dropped in a private compared to public context (i.e., the commercialisation effect) was because public scientists were trusted more than private scientists. This effect was consistent across all three SCR materials, suggesting that the use of mouse embryos or even iPSCs will not reduce the publics' concern with commercialised science. The implications these results have for public acceptance of stem cell and animal research are discussed in relation to possible solutions such as increasing public awareness of the regulation of animal research and benefit sharing. Springer Science+Business Media New York, 2013 Embryonic stem cell research nationallicence Public attitudes nationallicence Commercialisation of science nationallicence Animal experimentation nationallicence Trust in science nationallicence Critchley Christine Faculty of Life and Social Sciences, Swinburne University of Technology, Mail number: H31, P.O. Box 218, 3123, Hawthorn, Victoria, Australia aut Bruce Gordana Faculty of Life and Social Sciences, Swinburne University of Technology, Mail number: H31, P.O. Box 218, 3123, Hawthorn, Victoria, Australia aut Farrugia Matthew Faculty of Life and Social Sciences, Swinburne University of Technology, Mail number: H31, P.O. Box 218, 3123, Hawthorn, Victoria, Australia aut Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/5(2013-10-01), 541-554 1550-8943 9:5<541 2013 9 12015 https://doi.org/10.1007/s12015-013-9445-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9445-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Critchley Christine Faculty of Life and Social Sciences, Swinburne University of Technology, Mail number: H31, P.O. Box 218, 3123, Hawthorn, Victoria, Australia aut NATIONALLICENCE 700 1- Bruce Gordana Faculty of Life and Social Sciences, Swinburne University of Technology, Mail number: H31, P.O. Box 218, 3123, Hawthorn, Victoria, Australia aut NATIONALLICENCE 700 1- Farrugia Matthew Faculty of Life and Social Sciences, Swinburne University of Technology, Mail number: H31, P.O. Box 218, 3123, Hawthorn, Victoria, Australia aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/5(2013-10-01), 541-554 1550-8943 9:5<541 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer