naa a22 4500 510739539 CHVBK 20180411083023.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12015-013-9450-7 doi (NATIONALLICENCE)springer-10.1007/s12015-013-9450-7 Molecular Pathways Governing Development of Vascular Endothelial Cells from ES/iPS Cells [Elektronische Daten] [Keai Tan, Kiyomi Tamura, Mei Lai, Abhimanyu Veerakumarasivam, Yoichi Nakanishi, Minetaro Ogawa, Daisuke Sugiyama] Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type, including endothelial cells (ECs), and have been extensively used as in vitro models to analyze molecular mechanisms underlying EC generation and differentiation. The emergence of these promising new approaches suggests that ECs could be used in clinical therapy. Much evidence suggests that ES/iPS cell differentiation into ECs in vitro mimics the in vivo vascular morphogenic process. Through sequential steps of maturation, ECs derived from ES/iPS cells can be further differentiated into arterial, venous, capillary and lymphatic ECs, as well as smooth muscle cells. Here, we review EC development from ES/iPS cells with special attention to molecular pathways functioning in EC specification. Springer Science+Business Media New York, 2013 Endothelial cells nationallicence Differentiation nationallicence Molecular pathways nationallicence Embryonic stem cells nationallicence Induced pluripotent stem cells nationallicence Tan Keai ARO Center for Translational and Clinical Research, Kyushu University Hospital, Station for Collaborative Research 1, 4 F, 3-1-1 Maidashi, Higashi-Ku, 812-8582, Fukuoka, Japan aut Tamura Kiyomi Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, 860-0811, Kumamoto, Japan aut Lai Mei Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia aut Veerakumarasivam Abhimanyu Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia aut Nakanishi Yoichi ARO Center for Translational and Clinical Research, Kyushu University Hospital, Station for Collaborative Research 1, 4 F, 3-1-1 Maidashi, Higashi-Ku, 812-8582, Fukuoka, Japan aut Ogawa Minetaro Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, 860-0811, Kumamoto, Japan aut Sugiyama Daisuke ARO Center for Translational and Clinical Research, Kyushu University Hospital, Station for Collaborative Research 1, 4 F, 3-1-1 Maidashi, Higashi-Ku, 812-8582, Fukuoka, Japan aut Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/5(2013-10-01), 586-598 1550-8943 9:5<586 2013 9 12015 https://doi.org/10.1007/s12015-013-9450-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9450-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tan Keai ARO Center for Translational and Clinical Research, Kyushu University Hospital, Station for Collaborative Research 1, 4 F, 3-1-1 Maidashi, Higashi-Ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Tamura Kiyomi Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, 860-0811, Kumamoto, Japan aut NATIONALLICENCE 700 1- Lai Mei Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia aut NATIONALLICENCE 700 1- Veerakumarasivam Abhimanyu Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia aut NATIONALLICENCE 700 1- Nakanishi Yoichi ARO Center for Translational and Clinical Research, Kyushu University Hospital, Station for Collaborative Research 1, 4 F, 3-1-1 Maidashi, Higashi-Ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 700 1- Ogawa Minetaro Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, 860-0811, Kumamoto, Japan aut NATIONALLICENCE 700 1- Sugiyama Daisuke ARO Center for Translational and Clinical Research, Kyushu University Hospital, Station for Collaborative Research 1, 4 F, 3-1-1 Maidashi, Higashi-Ku, 812-8582, Fukuoka, Japan aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Springer US; http://www.springer-ny.com 9/5(2013-10-01), 586-598 1550-8943 9:5<586 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer