naa a22 4500 510739652 CHVBK 20180411083023.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12015-013-9430-y doi (NATIONALLICENCE)springer-10.1007/s12015-013-9430-y NK and MSCs Crosstalk: The Sense of Immunomodulation and Their Sensitivity [Elektronische Daten] [Javier Casado, R. Tarazona, F. Sanchez-Margallo] Several clinical trials are currently evaluating the safety and efficacy of mesenchymal stem cells (MSCs) in different diseases. The MSCs are guided by inflammatory mediators and specific interactions with immune cells occur, especially between MSCs and the cells of the innate immune system. At the present many of these interactions remain to be determined. This review summarizes the current knowledge in relation to the susceptibility of MSCs to NK cell mediated lysis as well as the immunomodulatory activity of MSCs and its control over NK cell function. Here we hypothesize that the inflammatory context will regulate the outcome of NK-MSC interactions. Springer Science+Business Media New York, 2013 NK cells nationallicence Mesenchymal stem cells nationallicence Immunomodulation nationallicence Innate Response nationallicence NK cell-mediated lysis nationallicence Casado Javier Stem Cell Therapy Unit, Minimally Invasive Surgery Centre Jesus Uson, Ctra. N-521 Km 41,8, 10071, Caceres, Spain aut Tarazona R. Immunology Unit, Department of Physiology, University of Extremadura, Caceres, Spain aut Sanchez-Margallo F. Stem Cell Therapy Unit, Minimally Invasive Surgery Centre Jesus Uson, Ctra. N-521 Km 41,8, 10071, Caceres, Spain aut Stem Cell Reviews and Reports Humana Press Inc 9/2(2013-04-01), 184-189 1550-8943 9:2<184 2013 9 12015 https://doi.org/10.1007/s12015-013-9430-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-013-9430-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Casado Javier Stem Cell Therapy Unit, Minimally Invasive Surgery Centre Jesus Uson, Ctra. N-521 Km 41,8, 10071, Caceres, Spain aut NATIONALLICENCE 700 1- Tarazona R. Immunology Unit, Department of Physiology, University of Extremadura, Caceres, Spain aut NATIONALLICENCE 700 1- Sanchez-Margallo F. Stem Cell Therapy Unit, Minimally Invasive Surgery Centre Jesus Uson, Ctra. N-521 Km 41,8, 10071, Caceres, Spain aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/2(2013-04-01), 184-189 1550-8943 9:2<184 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer