naa a22 4500 510739660 CHVBK 20180411083023.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12015-012-9423-2 doi (NATIONALLICENCE)springer-10.1007/s12015-012-9423-2 Specific Activity of Electron-Beam Synthesis Immobilized Hyaluronidase on G-CSF Induced Mobilization of Bone Marrow Progenitor Cells [Elektronische Daten] [A. Dygai, G. Zyuz'kov, V. Zhdanov, E. Udut, L. Miroshnichenko, E. Simanina, T. Khrichkova, M. Minakova, P. Madonov] The effects of nanotechnology (electron-beam) -PEGylated (or immobilized; Im) hyaluronidase (HD) on the state of the pool of bone marrow progenitor cells and their mobilization induced by granulocyte colony stimulating factor (G-CSF) were studied. A high specific activity of the drug Im-HD on progenitor cells of different classes was demonstrated using parenteral and enteral administration. An increase in the content of erythroid (E), granulomonocytic (GM), fibroblast (F) colony-forming units (CFU) and mesenchymal stem cells (MSC) in bone marrow was shown, as well as G-CSF-induced stimulation of mobilization of precursors into the peripheral blood under the influence of Im-HD. The detected activity of this novel drug on progenitor cells indicates the potential for a safe and highly effective treatment for hematology practice and regenerative medicine. Springer Science+Business Media New York, 2013 Progenitor cells nationallicence Mobilization nationallicence Immobilization nationallicence Pegylated hyaluronidase nationallicence Granulocytic colony stimulating factor nationallicence Nanotechnology nationallicence Dygai A. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Zyuz'kov G. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Zhdanov V. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Udut E. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Miroshnichenko L. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Simanina E. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Khrichkova T. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Minakova M. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Madonov P. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut Stem Cell Reviews and Reports Humana Press Inc 9/2(2013-04-01), 140-147 1550-8943 9:2<140 2013 9 12015 https://doi.org/10.1007/s12015-012-9423-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9423-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dygai A. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Zyuz'kov G. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Zhdanov V. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Udut E. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Miroshnichenko L. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Simanina E. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Khrichkova T. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Minakova M. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 700 1- Madonov P. Federal State Budgetary Institution, "Research Institute of Pharmacology” under the Siberian Branch of Russian Academy of Medical Sciences, Tomsk city (director - academician of RAMS A.M. Dygai), Lenin Avenue, 3 (Institute of Pharmacology of RAMS SB), 634028, Tomsk, Russia aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/2(2013-04-01), 140-147 1550-8943 9:2<140 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer