naa a22 4500 510739717 CHVBK 20180411083023.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12015-012-9419-y doi (NATIONALLICENCE)springer-10.1007/s12015-012-9419-y Cell Therapy with Bone Marrow Mononuclear Cells in Elastase-Induced Pulmonary Emphysema [Elektronische Daten] [Nathalia Longhini-dos-Santos, Valter Barbosa-de-Oliveira, Rodrigo Kozma, Carolina Faria, Talita Stessuk, Fernando Frei, João Ribeiro-Paes] Emphysema is characterized by destruction of alveolar walls with loss of gas exchange surface and consequent progressive dyspnea. This study aimed to evaluate the efficiency of cell therapy with bone marrow mononuclear cells (BMMC) in an animal model of elastase-induced pulmonary emphysema. Emphysema was induced in C57Bl/J6 female mice by intranasal instillation of elastase. After 21days, the mice received bone marrow mononuclear cells from EGFP male mice with C57Bl/J6 background. The groups were assessed by comparison and statistically significant differences (p < 0.05) were observed among the groups treated with BMMC and evaluated after 7, 14 and 21days. Analysis of the mean linear intercept (Lm) values for the different groups allowed to observe that the group treated with BMMC and evaluated after 21days showed the most significant result. The group that received no treatment showed a statistically significant difference when compared to other groups, except the group treated and evaluated after 21days, evidencing the efficacy of cell therapy with BMMC in pulmonary emphysema. Springer Science+Business Media New York, 2012 Pulmonary emphysema nationallicence COPD nationallicence Stem cells nationallicence Cell therapy nationallicence Animal model nationallicence Longhini-dos-Santos Nathalia Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut Barbosa-de-Oliveira Valter Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut Kozma Rodrigo Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut Faria Carolina Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut Stessuk Talita Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut Frei Fernando Department of Biological Sciences, University of the State of São Paulo - UNESP, Assis, SP, Brazil aut Ribeiro-Paes João Department of Biological Sciences, University of the State of São Paulo - UNESP, Assis, SP, Brazil aut Stem Cell Reviews and Reports Humana Press Inc 9/2(2013-04-01), 210-218 1550-8943 9:2<210 2013 9 12015 https://doi.org/10.1007/s12015-012-9419-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12015-012-9419-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Longhini-dos-Santos Nathalia Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Barbosa-de-Oliveira Valter Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Kozma Rodrigo Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Faria Carolina Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Stessuk Talita Inter-units Program of Post-Graduation in Biotechnology, University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Frei Fernando Department of Biological Sciences, University of the State of São Paulo - UNESP, Assis, SP, Brazil aut NATIONALLICENCE 700 1- Ribeiro-Paes João Department of Biological Sciences, University of the State of São Paulo - UNESP, Assis, SP, Brazil aut NATIONALLICENCE 773 0- Stem Cell Reviews and Reports Humana Press Inc 9/2(2013-04-01), 210-218 1550-8943 9:2<210 2013 9 12015 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer