naa a22 4500 510740227 CHVBK 20180411083025.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11845-012-0865-y doi (NATIONALLICENCE)springer-10.1007/s11845-012-0865-y Quigley E. Department of Medicine, Alimentary Pharmbiotic Centre, University College Cork, Cork University Hospital, Clinical Sciences Building, Cork, Ireland aut Bugs on the brain; brain in the gut—seeking explanations for common gastrointestinal symptoms [Elektronische Daten] [E. Quigley] Introduction: Gastrointestinal symptoms such as heartburn, indigestion (or dyspepsia), bloating, distension, constipation, abdominal pain, abdominal discomfort and diarrhoea are extremely common worldwide. For some, such symptoms can prove to be chronic and disabling. Methods: The recent literature on irritable bowel syndrome and, in particular, work emanating form this authors research group, was reviewed. Results: These functional symptoms commonly occur in aggregations, referred to as functional gastrointestinal disorders (FGIDs). Some of the FGIDs and, most notably irritable bowel syndrome (IBS), have achieved a degree of scientific and clinical credibility as coherent entities. Several lines of evidence ranging from gut motility to the microbiota are under investigation in attempts to explain IBS or its symptomatology. Conclusion: Though biomarkers for IBS and other FGIDs have proven elusive, considerable progress has been made in understanding possible aetiological factors in IBS; progress which may well lead to better therapeutic strategies. Royal Academy of Medicine in Ireland, 2012 Functional gastrointestinal disorders nationallicence Irritable bowel syndrome nationallicence Microbiota nationallicence Cytokines nationallicence Gut-brain axis nationallicence Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 1-6 0021-1265 182:1<1 2013 182 11845 https://doi.org/10.1007/s11845-012-0865-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0865-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Quigley E. Department of Medicine, Alimentary Pharmbiotic Centre, University College Cork, Cork University Hospital, Clinical Sciences Building, Cork, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 1-6 0021-1265 182:1<1 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer