naa a22 4500 510740243 CHVBK 20180411083025.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11845-012-0840-7 doi (NATIONALLICENCE)springer-10.1007/s11845-012-0840-7 The effect of behavioural risk factors on osteoporosis in Irish women [Elektronische Daten] [N. Cummins, P. Jakeman, I. Sestak, N. Murphy, P. Carroll] Background: Osteoporosis constitutes a major public health concern and its underlying pathogenesis is complex and multifactorial. Although hereditary factors strongly contribute to bone health, behavioural factors can modulate the genetically determined pattern of skeletal modelling and remodelling. Aim: The aim of this study was to investigate the effect(s) of behavioural risk factors on osteoporosis in Irish women. Methods: Pre- and post-menopausal adult women (n=189; 44±15years) participated in this cross-sectional study. Demographic, anthropometric and lifestyle data were collected during a single clinic visit. Dietary calcium intake and lifetime physical activity (PA) were assessed for each subject. Lumbar and femoral bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (DXA). Multivariate analysis was used to determine the independent predictors of low BMD. Results: Low BMD was present in 59% of subjects (42% pre- and 77% post-menopausal). Smoking was the strongest behavioural predictor of lumbar and femoral BMD. Age, height, family history, smoking, metabolic (MET) and mechanical (MECH) PA (lifetime) and weight (body mass) accounted for 39% of the variance in lumbar BMD. Age, height, family history, alcohol consumption, MET and MECH PA (lifetime) and weight accounted for 41% of the variance in femoral BMD. Conclusions: Prevalence of osteopenia and osteoporosis is high in Irish women and is associated with modifiable risk factors. A clearer focus should be paid to educate Irish women on preventative health behaviours for osteoporosis to curb the prevalence of this disease and the human and fiscal costs associated with it. Royal Academy of Medicine in Ireland, 2012 Behavioural risk factors nationallicence Osteoporosis nationallicence Prevalence nationallicence Prevention nationallicence Ireland nationallicence Cummins N. 4i Centre for Interventions in Infection, Inflammation and Immunity, Graduate Entry Medical School, University of Limerick, National Technological Park, Limerick, Ireland aut Jakeman P. 4i Centre for Interventions in Infection, Inflammation and Immunity, Graduate Entry Medical School, University of Limerick, National Technological Park, Limerick, Ireland aut Sestak I. Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary University of London, London, UK aut Murphy N. Centre for Health Behaviour Research, Waterford Institute of Technology, Waterford, Ireland aut Carroll P. Centre for Health Behaviour Research, Waterford Institute of Technology, Waterford, Ireland aut Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 97-105 0021-1265 182:1<97 2013 182 11845 https://doi.org/10.1007/s11845-012-0840-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0840-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cummins N. 4i Centre for Interventions in Infection, Inflammation and Immunity, Graduate Entry Medical School, University of Limerick, National Technological Park, Limerick, Ireland aut NATIONALLICENCE 700 1- Jakeman P. 4i Centre for Interventions in Infection, Inflammation and Immunity, Graduate Entry Medical School, University of Limerick, National Technological Park, Limerick, Ireland aut NATIONALLICENCE 700 1- Sestak I. Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Queen Mary University of London, London, UK aut NATIONALLICENCE 700 1- Murphy N. Centre for Health Behaviour Research, Waterford Institute of Technology, Waterford, Ireland aut NATIONALLICENCE 700 1- Carroll P. Centre for Health Behaviour Research, Waterford Institute of Technology, Waterford, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 97-105 0021-1265 182:1<97 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer