naa a22 4500 510740286 CHVBK 20180411083025.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11845-012-0818-5 doi (NATIONALLICENCE)springer-10.1007/s11845-012-0818-5 Immunomodulators for multiple sclerosis may ameliorate spinal bone loss [Elektronische Daten] [M. McKenna, B. Murray, R. Lonergan, J. Redmond] Background: The effect of immunomodulator therapy (IMT) for multiple sclerosis (MS) on bone turnover is unknown. Aim: The aim of this study was to assess bone turnover in MS patients on IMT. Methods: MS patients (n=29) on maintenance IMT had repeat measurement of bone mineral density (BMD) after a 4.0±0.4years; bone turnover markers (BTM) were measured at the time of repeat BMD. Results: BMD was unchanged at the spine but declined at the hip. BTMs, both resorption and formation, were reduced compared to normative range that may indicate an anti-resorptive action of IMT. Significant negative correlations were noted between BTMs and changes in BMD at spine but not hip. Conclusion: These observations suggest that IMT may have a beneficial effect on spinal bone by an antiresorptive action. A prospective study of the effect of IMT on BMD and bone turnover is warranted. Royal Academy of Medicine in Ireland, 2012 Multiple sclerosis nationallicence Immunodulator therapy nationallicence Bone mineral density nationallicence Bone turnover markers nationallicence McKenna M. DXA Unit, St. Vincent's University Hospital, 4, Dublin, Ireland aut Murray B. Metabolism Laboratory, St. Vincent's University Hospital, Dublin, Ireland aut Lonergan R. Department of Neurology, St. James's Hospital, Dublin, Ireland aut Redmond J. Department of Neurology, St. James's Hospital, Dublin, Ireland aut Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 29-32 0021-1265 182:1<29 2013 182 11845 https://doi.org/10.1007/s11845-012-0818-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0818-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McKenna M. DXA Unit, St. Vincent's University Hospital, 4, Dublin, Ireland aut NATIONALLICENCE 700 1- Murray B. Metabolism Laboratory, St. Vincent's University Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Lonergan R. Department of Neurology, St. James's Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Redmond J. Department of Neurology, St. James's Hospital, Dublin, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 29-32 0021-1265 182:1<29 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer