naa a22 4500 510740367 CHVBK 20180411083026.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11845-012-0827-4 doi (NATIONALLICENCE)springer-10.1007/s11845-012-0827-4 Comparison of Maddrey Discriminant Function, Child-Pugh Score and Glasgow Alcoholic Hepatitis Score in predicting 28-day mortality on admission in patients with acute hepatitis [Elektronische Daten] [S. Ali, S. Hussain, M. Hair, A. Shah] Background: Acute hepatitis (AH) in patients with chronic alcoholic liver disease is associated with high mortality. It is therefore vital to identify patients at greatest risk of mortality who may benefit from aggressive intervention. The scoring systems used to assess the severity of AH [Maddrey Discriminant Function (mDF), Child-Pugh Score (CPS) and Glasgow Alcoholic Hepatitis Score (GAHS)] have shown to be useful in determining severity and predicting mortality in these patients. Aim: The aim of this study was to compare three scoring systems in predicting 28-day mortality in AH on admission. Method and results: Case notes of 82 patients with AH were reviewed on admission; mDF, CPS, GAHS were calculated and their outcome recorded on day 28. Thirty-six patients (44%) died within 28days of admission. There was no difference in the age of patients who survived (51.2±11years) and those who died (52.6±10years). However, mDF, CPS and GAHS were significantly higher in dead patients (68.7±56.4, 11.8±1.3, 8.6±1.6, respectively) compared to those who survived (36.2±25.9, 10±1.6, 7.6±1.5, respectively) (p<0.01). Similarly, prothrombin time (PT) was significantly higher in patients who died (23±2s) compared to those who survived (17.6±0.7s) (p=0.007). Conclusion: There was no difference among three scoring systems in predicting 28-day mortality at the time of admission in patients with AH. In addition, increased PT, gastro-intestinal bleeding and advanced encephalopathy at presentation were associated with high mortality. Furthermore, rise in creatinine from admission increased risk of mortality. Royal Academy of Medicine in Ireland, 2012 Alcohol liver disease nationallicence Maddrey Discriminant Function nationallicence Child-Pugh Score nationallicence Glasgow nationallicence Alcoholic Hepatitis Score nationallicence Severity indexes of alcoholic hepatitis nationallicence Ali S. Department of Gastroenterology and Hepatology, Crosshouse Hospital, KA2 0BE, Kilmarnock, UK aut Hussain S. Department of Gastroenterology and Hepatology, St. Luke's Roosevelt-Hospital, Columbia College of Physicians and Surgeons, New York, USA aut Hair M. Department of Mathematics and Statistics, University of the West of Scotland, PA1 2 BE, Paisley, UK aut Shah A. Department of Gastroenterology and Hepatology, Crosshouse Hospital, KA2 0BE, Kilmarnock, UK aut Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 63-68 0021-1265 182:1<63 2013 182 11845 https://doi.org/10.1007/s11845-012-0827-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0827-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ali S. Department of Gastroenterology and Hepatology, Crosshouse Hospital, KA2 0BE, Kilmarnock, UK aut NATIONALLICENCE 700 1- Hussain S. Department of Gastroenterology and Hepatology, St. Luke's Roosevelt-Hospital, Columbia College of Physicians and Surgeons, New York, USA aut NATIONALLICENCE 700 1- Hair M. Department of Mathematics and Statistics, University of the West of Scotland, PA1 2 BE, Paisley, UK aut NATIONALLICENCE 700 1- Shah A. Department of Gastroenterology and Hepatology, Crosshouse Hospital, KA2 0BE, Kilmarnock, UK aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/1(2013-03-01), 63-68 0021-1265 182:1<63 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer