naa a22 4500 510740677 CHVBK 20180411083027.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11845-012-0895-5 doi (NATIONALLICENCE)springer-10.1007/s11845-012-0895-5 Through the looking glass; bioactive glass S53P4 (BonAlive®) in the treatment of chronic osteomyelitis [Elektronische Daten] [J. McAndrew, C. Efrimescu, E. Sheehan, D. Niall] Background: In terms of eradication, osteomyelitis represents one of the most challenging infective conditions in medicine and surgery. In recent years, the use of bioactive glass in conjunction with antimicrobial therapy has emerged as a viable new treatment. Aim: We present a short study, from a regional orthopaedic unit, demonstrating its successful use in three patients with chronic osteomyelitis. Methods: Between September 2010 and May 2011, bioactive glass S53P4 was used in conjunction with intravenous and oral antibiotics to treat chronic osteomyelitis in three patients (two male, one female). All patients underwent debridement and sequestrectomy procedures with the insertion of bioactive glass followed by antimicrobial regimens tailored to isolated pathogen sensitivities. Patient age ranged from 28 to 68years, with a mean age of 44.7years. The presentation period, from time of initial diagnosis to treatment, varied from 16months to 16years and all three patients had underwent multiple previous debridements and antimicrobial regimens to no avail. Results: A follow-up of 14-21months has been achieved with a mean follow-up of 17.3months. We have seen excellent results in all three patients. All haematological and biochemical parameters have returned to normal, pain has ceased and function has returned in the affected limbs. All antibiotics have stopped and there is no radiological evidence of osteomyelitis. The bioactive glass has integrated with the surrounding bone. Conclusions: Though a relatively recent development, bioactive glass used in concurrence with antibiotic therapy has significant potential in the treatment of chronic osteomyelitis. Royal Academy of Medicine in Ireland, 2013 McAndrew J. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut Efrimescu C. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut Sheehan E. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut Niall D. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut Irish Journal of Medical Science Springer-Verlag 182/3(2013-09-01), 509-511 0021-1265 182:3<509 2013 182 11845 https://doi.org/10.1007/s11845-012-0895-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0895-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McAndrew J. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut NATIONALLICENCE 700 1- Efrimescu C. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut NATIONALLICENCE 700 1- Sheehan E. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut NATIONALLICENCE 700 1- Niall D. Department of Orthopaedic Surgery, Midland Regional Hospital, Tullamore, County Offaly, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/3(2013-09-01), 509-511 0021-1265 182:3<509 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer