naa a22 4500 510741142 CHVBK 20180411083028.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11845-013-0926-x doi (NATIONALLICENCE)springer-10.1007/s11845-013-0926-x Evaluation of the effects of ozone therapy on Escherichia coli -induced cytitis in rat [Elektronische Daten] [C. Tasdemir, S. Tasdemir, N. Vardi, B. Ates, Y. Onal, S. Erdogan, A. Yucel, E. Aglamis, Y. Yakupogullari, R. Altıntas, A. Karaman] Objectives: The aim of the study was to investigate the effect of ozone on oxidative/nitrosative stress and bladder injury caused by Escherichia coli in rat bladder. Methods: Twenty-one Wistar-Albino-type female rats included in the study were divided into three groups of equal number: (1) sham operation (control), (2) E. coli-only (EC), (3) EC+ozone. After ozone therapy for 3days, urine and tissue samples were obtained for biochemical, microbiological, and histopathological analysis. Results: Tissue malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) level were increased, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was decreased in the EC group. MDA, MPO, and NO levels were decreased, whereas SOD, GPx activity was increased in the ozone-treated group. Also, there was no bacterial translocation in this group. Conclusion: The results of the present study suggest that ozone may be used as an agent to protect the bladder from oxidative/nitrosative stress occurring in cystitis. Royal Academy of Medicine in Ireland, 2013 Ozone nationallicence Cystitis nationallicence Rats nationallicence Oxidative stress nationallicence Tasdemir C. Department of Urology, School of Medicine, Inonu University, Malatya, Turkey aut Tasdemir S. Department of Pharmacology, School of Medicine, Inonu University, Malatya, Turkey aut Vardi N. Department of Histology, School of Medicine, Inonu University, Malatya, Turkey aut Ates B. Department of Chemistry, School of Science Art, Inonu University, Malatya, Turkey aut Onal Y. Department of Chemical Engineering, School of Engineering, Inonu University, Malatya, Turkey aut Erdogan S. Department of Chemistry, School of Science Art, Inonu University, Malatya, Turkey aut Yucel A. Department of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey aut Aglamis E. Department of Urology, Elazig Education Research Hospital, Elazig, Turkey aut Yakupogullari Y. Department of Microbiology and Clinic Microbiology, School of Medicine, Inonu University, Malatya, Turkey aut Altıntas R. Department of Urology, School of Medicine, Inonu University, Malatya, Turkey aut Karaman A. Department of Pediatric Surgery and Urology, School of Medicine, Inonu University, Malatya, Turkey aut Irish Journal of Medical Science Springer London 182/4(2013-12-01), 557-563 0021-1265 182:4<557 2013 182 11845 https://doi.org/10.1007/s11845-013-0926-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-013-0926-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tasdemir C. Department of Urology, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Tasdemir S. Department of Pharmacology, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Vardi N. Department of Histology, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Ates B. Department of Chemistry, School of Science Art, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Onal Y. Department of Chemical Engineering, School of Engineering, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Erdogan S. Department of Chemistry, School of Science Art, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Yucel A. Department of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Aglamis E. Department of Urology, Elazig Education Research Hospital, Elazig, Turkey aut NATIONALLICENCE 700 1- Yakupogullari Y. Department of Microbiology and Clinic Microbiology, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Altıntas R. Department of Urology, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 700 1- Karaman A. Department of Pediatric Surgery and Urology, School of Medicine, Inonu University, Malatya, Turkey aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer London 182/4(2013-12-01), 557-563 0021-1265 182:4<557 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer