naa a22 4500 510741274 CHVBK 20180411083029.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11845-013-0931-0 doi (NATIONALLICENCE)springer-10.1007/s11845-013-0931-0 Peripheral blood CD40-CD40L expression in human breast cancer [Elektronische Daten] [W. Pan, J. Gong, C. Yang, R. Feng, F. Guo, Y. Sun, H. Chen] Background: Breast cancer is the most common cancer in women. T cell-based immunotherapy for cancer has attracted much attention recently. CD40 and CD40L occupy an important position of specific immune response. In this paper, we want to study the role of co-stimulatory molecules CD40/CD40L and their clinical significance in peripheral blood of patients with breast cancer. Methods: Thirty breast cancer patients served as observation group, who were diagnosed as having infiltrating ductal breast cancer histopathologically, and 30 healthy as control group. Flow cytometric analysis was conducted to detect the expression of CD40 and CD40L on B and T lymphocytes in peripheral blood. The relationship between the CD40/CD40L expression levels and pathological grades was analyzed. Results: The expression levels of CD40/CD40L on B cells and T cells in breast cancer patients were significantly higher than those in the controls (all P<0.001), and CD40/CD40L levels had a significant positive relationship with pathological grades (all P<0.001). Conclusions: The upregulated levels of co-stimulators CD40/CD40L on B cells and T cells may play an important role in the immune pathogenesis of breast cancer. Royal Academy of Medicine in Ireland, 2013 Breast cancer nationallicence Co-stimulatory molecule nationallicence Peripheral blood nationallicence CD40 nationallicence CD40L nationallicence Pan W. Liaoning Center for Disease Control and Prevention, No. 242 Shayang Road, 110005, Shenyang, People's Republic of China aut Gong J. Department of Clinical Pharmacy, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, Shenyang, People's Republic of China aut Yang C. Department of Pancreatic and Thyroid Shengjing Hospital, China Medical University, 110004, Shenyang, People's Republic of China aut Feng R. Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, 110001, Shenyang, People's Republic of China aut Guo F. Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, 110001, Shenyang, People's Republic of China aut Sun Y. Women's and Children's Hospital, 110011, Shenyang, People's Republic of China aut Chen H. Haidian Center for Disease Control and Prevention, 100094, Beijing, People's Republic of China aut Irish Journal of Medical Science Springer London 182/4(2013-12-01), 719-721 0021-1265 182:4<719 2013 182 11845 https://doi.org/10.1007/s11845-013-0931-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-013-0931-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pan W. Liaoning Center for Disease Control and Prevention, No. 242 Shayang Road, 110005, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Gong J. Department of Clinical Pharmacy, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Yang C. Department of Pancreatic and Thyroid Shengjing Hospital, China Medical University, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Feng R. Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, 110001, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Guo F. Department of Pharmaceutical Toxicology, School of Pharmaceutical Science, China Medical University, 110001, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Sun Y. Women's and Children's Hospital, 110011, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Chen H. Haidian Center for Disease Control and Prevention, 100094, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer London 182/4(2013-12-01), 719-721 0021-1265 182:4<719 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer