naa a22 4500 510741282 CHVBK 20180411083029.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11845-013-0963-5 doi (NATIONALLICENCE)springer-10.1007/s11845-013-0963-5 The effects of angiotensin-converting enzyme-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats [Elektronische Daten] [F. Hong, H. Junling, S. Yi, L. Chi, Z. Huan, D. Yu qing, L. Lingxia, G. Yang, L. Ming] Objective: To investigate the protective effect of angiotensin-converting enzyme (ACE)-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats (SHRs). Methods: A cohort of male SHRs were randomly divided into three groups (n=10 for each group): pseudo-experimental group, enalapril-treated group as a positive control group, ACE-inhibitory peptide LAP-treated group. After the experiment, the left common carotid artery from each rat was removed for morphological evaluation. Results: It was observed that the vascular medial thickness, media thickness/lumen diameter, medial cross-sectional area and mean nuclear area of smooth muscle cells of the left common carotid artery in the LAP group or enalapril group were significantly lower than those in the pseudo-experimental group, while there was no significant difference in these parameters observed between the LAP group and enalapril group. Additionally, the vascular area percentage of collagen fibers of the left common carotid artery in the LAP group and enalapril group was significantly lower than that of the pseudo-experimental group. Conclusions: The protective vessel remodeling effect in SHRs was observed with ACE-inhibitory peptide LAP in SHRs by decreasing blood pressure, inhibiting smooth muscle cell hypertrophy and reducing the proliferation of collagen fibers. Royal Academy of Medicine in Ireland, 2013 Angiotensin-converting enzyme (ACE)-inhibitory peptide nationallicence Hypertension nationallicence Vascular remodeling nationallicence Mechanism nationallicence Hong F. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Junling H. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Yi S. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Chi L. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Huan Z. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Yu qing D. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Lingxia L. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Yang G. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Ming L. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut Irish Journal of Medical Science Springer London 182/4(2013-12-01), 711-718 0021-1265 182:4<711 2013 182 11845 https://doi.org/10.1007/s11845-013-0963-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-013-0963-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hong F. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Junling H. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Yi S. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Chi L. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Huan Z. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Yu qing D. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Lingxia L. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Yang G. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 700 1- Ming L. Department of Cardiology, Tongji Hospital Affiliated to Tongji University, 200065, Shanghai, China aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer London 182/4(2013-12-01), 711-718 0021-1265 182:4<711 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer