naa a22 4500 510741304 CHVBK 20180411083029.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s11845-013-0957-3 doi (NATIONALLICENCE)springer-10.1007/s11845-013-0957-3 Helicobacter pylori resistance rates for levofloxacin, tetracycline and rifabutin among Irish isolates at a reference centre [Elektronische Daten] [A. O'Connor, I. Taneike, A. Nami, N. Fitzgerald, B. Ryan, N. Breslin, H. O'Connor, D. McNamara, P. Murphy, C. O'Morain] Introduction: Helicobacter pylori eradication rates using conventional triple therapies are falling, making viable second-line and rescue regimens necessary. Levofloxacin, tetracycline and rifabutin are three efficacious antibiotics for rescue therapy. Aim: We aimed to assess the resistance rates for H. pylori against these antibiotics in an Irish cohort. Methods: Gastric biopsies were collected from 85 patients infected with H. pylori (mean age 46years) in the Adelaide and Meath Hospital, Dublin in 2008 and 2009. Susceptibility to antibiotics was tested using the Etest. Clinical information was obtained from endoscopy reports and chart review. Results: 50.6% of patients were females. Mean age was 47years. Ten had prior attempts at eradication therapy with amoxicillin-clarithromycin-PPI, two had levofloxacin-based second-line therapy. 11.7% [95% CI (6.5-20.3%)] (N=10) had strains resistant to levofloxacin. There were no strains resistant to rifabutin or tetracycline. Levofloxacin resistance in the under 45 age group was 2.6% (1/38) compared to 19.1% (9/47) of above 45 age group (p=0.02). Discussion: The levofloxacin rates illustrated in this study are relatively low by European standards and in line with other studies from the United Kingdom and Germany, with younger patients having very low levels of resistance. Levofloxacin, tetracycline and rifabutin are all valid options for H. pylori eradication in Irish patients but the importance of compliance cannot be underestimated. Royal Academy of Medicine in Ireland, 2013 Helicobacter pylori nationallicence Resistance nationallicence Compliance nationallicence Levofloxacin nationallicence Rifabutin nationallicence Tetracycline nationallicence O'Connor A. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Taneike I. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Nami A. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Fitzgerald N. Department of Microbiology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Ryan B. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Breslin N. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut O'Connor H. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut McNamara D. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Murphy P. Department of Microbiology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut O'Morain C. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut Irish Journal of Medical Science Springer London 182/4(2013-12-01), 693-695 0021-1265 182:4<693 2013 182 11845 https://doi.org/10.1007/s11845-013-0957-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-013-0957-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Connor A. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- Taneike I. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- Nami A. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- Fitzgerald N. Department of Microbiology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- Ryan B. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- Breslin N. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- O'Connor H. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- McNamara D. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- Murphy P. Department of Microbiology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 700 1- O'Morain C. Department of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght, Dublin 24, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer London 182/4(2013-12-01), 693-695 0021-1265 182:4<693 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer