naa a22 4500 51074141X CHVBK 20180411083029.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11845-012-0863-0 doi (NATIONALLICENCE)springer-10.1007/s11845-012-0863-0 Surgical resection for non-small cell lung cancer: clinical features and outcomes for a consecutive series at an Irish tertiary referral centre [Elektronische Daten] [B. Al-Alao, D. O'Callaghan, K. Gately, S. Nicholson, L. Coate, F. O'Connell, E. McGovern, K. O'Byrne, V. Young] Background: Few patients diagnosed with lung cancer are still alive 5years after diagnosis. The aim of the current study was to conduct a 10-year review of a consecutive series of patients undergoing curative-intent surgical resection at the largest tertiary referral centre to identify prognostic factors. Methods: Case records of all patients operated on for lung cancer between 1998 and 2008 were reviewed. The clinical features and outcomes of all patients with non-small cell lung cancer (NSCLC) stage I-IV were recorded. Results: A total of 654 patients underwent surgical resection with curative intent during the study period. Median overall survival for the entire cohort was 37months. The median age at operation was 66years, with males accounting for 62.7%. Squamous cell type was the most common histological subtype, and lobectomies were performed in 76.5% of surgical resections. Pneumonectomy rates decreased significantly in the latter half of the study (25 vs. 16.3%), while sub-anatomical resection more than doubled (2 vs. 5%) (p<0.005). Clinico-pathological characteristics associated with improved survival by univariate analysis include younger age, female sex, smaller tumour size, smoking status, lobectomy, lower T and N status and less advanced pathological stage. Age, gender, smoking status and tumour size, as well as T and N descriptors have emerged as independent prognostic factors by multivariate analysis. Conclusion: We identified several factors that predicted outcome for NSCLC patients undergoing curative-intent surgical resection. Survival rates in our series are comparable to those reported from other thoracic surgery centres. Royal Academy of Medicine in Ireland, 2012 Non-small cell lung cancer nationallicence Surgery nationallicence Survival nationallicence Outcome nationallicence Prognostic factors and prognosis nationallicence Al-Alao B. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut O'Callaghan D. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut Gately K. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut Nicholson S. LABMED Directorates, St. James's Hospital, Dublin 8, Ireland aut Coate L. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut O'Connell F. CREST Directorate, Department of Cardiothoracic Surgery, St James's Hospital, Dublin 8, Ireland aut McGovern E. CREST Directorate, Department of Cardiothoracic Surgery, St James's Hospital, Dublin 8, Ireland aut O'Byrne K. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut Young V. CREST Directorate, Department of Cardiothoracic Surgery, St James's Hospital, Dublin 8, Ireland aut Irish Journal of Medical Science Springer-Verlag 182/2(2013-06-01), 217-225 0021-1265 182:2<217 2013 182 11845 https://doi.org/10.1007/s11845-012-0863-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0863-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Al-Alao B. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- O'Callaghan D. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Gately K. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Nicholson S. LABMED Directorates, St. James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Coate L. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- O'Connell F. CREST Directorate, Department of Cardiothoracic Surgery, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- McGovern E. CREST Directorate, Department of Cardiothoracic Surgery, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- O'Byrne K. Thoracic Oncology Research Group, St. James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 700 1- Young V. CREST Directorate, Department of Cardiothoracic Surgery, St James's Hospital, Dublin 8, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/2(2013-06-01), 217-225 0021-1265 182:2<217 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer