naa a22 4500 510741614 CHVBK 20180411083030.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s11845-012-0858-x doi (NATIONALLICENCE)springer-10.1007/s11845-012-0858-x Aggressive giant cell granuloma of the jaws treated with interferon alpha: a report of two cases [Elektronische Daten] [J. O'Connell, G. Kearns] Background: Giant cell granulomas (GCGs) are benign tumours of the jaws of unknown aetiology. Aggressive lesions are difficult to manage and demonstrate a tendency to recur after surgical curettage. In the early 1980s, interferon alpha-2a was found to inhibit angiogenesis through a series of laboratory experiments and was subsequently used to treat a child with pulmonary haemangiomatosis. It has been hypothesised that GCGs are proliferative vascular lesions and would, therefor, be expected to respond to antiangiogenic therapy. The purpose of this study is to report a treatment protocol consisting of enucleation, followed by subcutaneous interferon alpha. Methods: Patients with a biopsy-confirmed giant cell lesion satisfying criteria for "aggressive” giant cell tumours were included. All lesions were enucleated, and the patients commenced interferon alpha-2a (3,000,000 units/m2) 48-72h post-operatively. Results: Two patients satisfied the criteria for aggressive giant cell lesions. All tumours were enucleated. There were no post-operative complications, and all patients tolerated the interferon therapy well. To date, there has been no evidence of tumour recurrence. The follow-up periods were 144 and 81months, respectively. Conclusion: Antiangiogenic therapy, in combination with curettage, has proven to be a useful strategy for the management of these tumours. The use of interferon alpha-2a, following enucleation of these lesions, resulted in complete remission of all lesions, and decreased operative morbidity compared with conventional treatment. Royal Academy of Medicine in Ireland, 2012 Aggressive giant cell granuloma nationallicence Interferon nationallicence Interferon alpha nationallicence Giant cell tumour of the jaws nationallicence O'Connell J. Department of Oral and Maxillofacial Surgery, St James's Hospital, Dublin, Ireland aut Kearns G. Department of Oral and Maxillofacial Surgery, St James's Hospital, Dublin, Ireland aut Irish Journal of Medical Science Springer-Verlag 182/2(2013-06-01), 163-170 0021-1265 182:2<163 2013 182 11845 https://doi.org/10.1007/s11845-012-0858-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11845-012-0858-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Connell J. Department of Oral and Maxillofacial Surgery, St James's Hospital, Dublin, Ireland aut NATIONALLICENCE 700 1- Kearns G. Department of Oral and Maxillofacial Surgery, St James's Hospital, Dublin, Ireland aut NATIONALLICENCE 773 0- Irish Journal of Medical Science Springer-Verlag 182/2(2013-06-01), 163-170 0021-1265 182:2<163 2013 182 11845 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer