naa a22 4500 51074267X CHVBK 20180411083033.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12630-013-9914-x doi (NATIONALLICENCE)springer-10.1007/s12630-013-9914-x In non-obese patients, duration of action of rocuronium is directly correlated with body mass index [Elektronische Daten] [Masafumi Fujimoto, Chiyoko Tanahira, Masaaki Nishi, Tatsuo Yamamoto] Chez les patientes non obèses, la durée d'action du rocuronium est directement corrélée à l'indice de masse corporelle Background: Administration of neuromuscular blocking agents using a dose calculated on actual body weight carries a risk of prolonged duration of action in obese patients whose body mass index (BMI) is>30kg·m−2. In the present study, we hypothesized that there could be a correlation between BMI and the duration of action of rocuronium administered according to actual body weight in non-obese patients, in particular, overweight (BMI 25-30kg·m−2) and underweight patients (BMI<18.5kg·m−2). Methods: Sixteen female patients (BMI 15-30kg·m−2, aged 45-60yr) scheduled for elective surgery under total intravenous anesthesia were included in this study. Rocuronium 0.9mg·kg−1 was administered, and adductor pollicis train-of-four responses following ulnar nerve stimulation were monitored every minute with acceleromyography. The times from the injection of rocuronium until spontaneous recovery of first twitch to 5% (5% Duration) and 25% (25% Duration) of baseline were measured, and the correlation with BMI was analyzed. Results: A significant correlation between 5% Duration and BMI (r2=0.56; P<0.001) was found by linear regression analysis. A significant correlation was also found between 25% Duration and BMI (r2=0.49; P=0.003). Conclusion: In adult female patients with a BMI in the range of 15-30kg·m−2, the duration of action of rocuronium increases with BMI when the drug is administered on the basis of mg per actual kg body weight. Canadian Anesthesiologists' Society, 2013 Fujimoto Masafumi Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut Tanahira Chiyoko Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut Nishi Masaaki Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut Yamamoto Tatsuo Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/6(2013-06-01), 552-556 0832-610X 60:6<552 2013 60 12630 https://doi.org/10.1007/s12630-013-9914-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9914-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujimoto Masafumi Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut NATIONALLICENCE 700 1- Tanahira Chiyoko Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut NATIONALLICENCE 700 1- Nishi Masaaki Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut NATIONALLICENCE 700 1- Yamamoto Tatsuo Department of Anesthesiology, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, 1-1-1, Honjyo, Cyuoku, 860-8556, Kumamoto-City, Kumamoto, Japan aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/6(2013-06-01), 552-556 0832-610X 60:6<552 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer