naa a22 4500 510743013 CHVBK 20180411083034.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12630-013-9986-7 doi (NATIONALLICENCE)springer-10.1007/s12630-013-9986-7 Automatic administration of propofol and remifentanil guided by the bispectral index during rigid bronchoscopic procedures: a randomized trial [Elektronische Daten] [Ngai Liu, Olivier Pruszkowski, Jérôme Leroy, Thierry Chazot, Bernard Trillat, Arlette Colchen, François Gonin, Marc Fischler] Administration automatique du propofol et du rémifentanil selon l'indice bispectral pendant des bronchoscopes rigides: une étude randomisée Background: Anesthesia for rigid bronchoscopic procedures is a demanding procedure. Automatic titration of propofol and remifentanil to maintain the bispectral index (BIS) within the recommended range (40-60) has been reported during routine surgical procedures. The aim of the present study was to evaluate its use during rigid bronchoscopy. Methods: Patients were enrolled in a randomized study comparing manual target-controlled infusion of propofol and remifentanil (manual TCI group) with automatic titration guided by the BIS (dual-loop group). Categorical variables were compared by the Fisher's exact test, and continuous variables (median [interquartile range 25-75]) were compared by the Mann-Whitney test. Results: Thirty-four patients were included in the manual TCI group and 33 were included in the dual-loop group. Baseline characteristics were well balanced between the groups. Intervention by the anesthesiologist in charge to modify propofol and/or remifentanil targets in the dual-loop group was not necessary. Percentage of time spent in the BIS interval (40-60) was similar in the manual TCI and dual-loop groups (69% [48-79] vs 70% [58-80], respectively). Durations of induction and of maintenance and propofol and remifentanil doses were also similar between groups, except for the amount of propofol needed for induction (P=0.002). Time to tracheal extubation was also similar. No case of intraoperational awareness was detected. Conclusion: The present study could not establish the superiority of automatic system over manual adjustment for bronchoscopy. Further studies with a different design and a larger number of patients are required to establish the place of automatic delivery of anesthetic agents. This study was registered at ClinicalTrials.gov number, NCT00571181. Canadian Anesthesiologists' Society, 2013 Liu Ngai Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut Pruszkowski Olivier Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut Leroy Jérôme Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut Chazot Thierry Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut Trillat Bernard Department of Informatics, Hôpital Foch, Suresnes, France aut Colchen Arlette Université Versailles Saint-Quentin en Yvelines, Versailles, Saint-Quentin en Yvelines, France aut Gonin François Université Versailles Saint-Quentin en Yvelines, Versailles, Saint-Quentin en Yvelines, France aut Fischler Marc Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/9(2013-09-01), 881-887 0832-610X 60:9<881 2013 60 12630 https://doi.org/10.1007/s12630-013-9986-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9986-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Ngai Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut NATIONALLICENCE 700 1- Pruszkowski Olivier Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut NATIONALLICENCE 700 1- Leroy Jérôme Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut NATIONALLICENCE 700 1- Chazot Thierry Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut NATIONALLICENCE 700 1- Trillat Bernard Department of Informatics, Hôpital Foch, Suresnes, France aut NATIONALLICENCE 700 1- Colchen Arlette Université Versailles Saint-Quentin en Yvelines, Versailles, Saint-Quentin en Yvelines, France aut NATIONALLICENCE 700 1- Gonin François Université Versailles Saint-Quentin en Yvelines, Versailles, Saint-Quentin en Yvelines, France aut NATIONALLICENCE 700 1- Fischler Marc Department of Anesthesiology, Hôpital Foch, 40 rue Worth, 92151, Suresnes, France aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/9(2013-09-01), 881-887 0832-610X 60:9<881 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer