naa a22 4500 510743129 CHVBK 20180411083035.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12630-013-9989-4 doi (NATIONALLICENCE)springer-10.1007/s12630-013-9989-4 Butorphanol prevents morphine-induced pruritus without increasing pain and other side effects: a systematic review of randomized controlled trials [Elektronische Daten] [Bo-Xiang Du, Zhe-Ming Song, Kai Wang, Hao Zhang, Feng-Ying Xu, Zui Zou, Xue-Yin Shi] Le butorphanol prévient le prurit induit par la morphine sans augmentation de la douleur et des autres effets secondaires: une revue méthodique des études randomisées contrôlées Purpose: Pruritus is a frequent adverse event after administration of morphine. Butorphanol has been used to prevent morphine-induced pruritus, but its efficacy is still controversial. The aim of this systematic review was to evaluate the efficacy of using butorphanol to prevent morphine-induced pruritus. Source: We searched PubMed, Cochrane Library, EMBASE, and China's BioMedical Disc for full reports of randomized controlled trials that compared the use of butorphanol with either placebo or no treatment for preventing morphine-induced pruritus. The number of patients experiencing pruritus or other side effects was analyzed using relative risk (RR) with 95% confidence intervals (CI). Principal findings: Sixteen trials (795 patients) were analyzed. Continuous intravenous and epidural butorphanol reduced pruritus with RR 0.22 (95% CI 0.10 to 0.45) and RR 0.24 (95% CI 0.16 to 0.36), respectively. Use of epidural butorphanol decreased the number of patients requesting rescue treatment for pruritus (RR 0.57; 95% CI 0.41 to 0.81). Butorphanol decreased postoperative pain intensity at four, eight, and 12hr with standardized mean differences of −0.29 (95% CI −0.52 to −0.05), −0.30 (95% CI −0.56 to −0.04), and −0.23 (95% CI −0.46 to −0.01), respectively. Epidural but not intravenous butorphanol reduced postoperative nausea and vomiting (PONV) (RR 0.35; 95% CI 0.19 to 0.66). Butorphanol did not increase respiratory depression (RR 0.71; 95% CI 0.31 to 1.63), somnolence (RR 0.71; 95% CI 0.22 to 2.37), or dizziness (RR 2.45; 95% CI 0.35 to 17.14). Conclusion: Butorphanol administered with morphine may be an effective strategy for preventing morphine-induced pruritus as it decreases pain intensity and PONV without increasing other side effects. Thus, it can be recommended for preventing morphine-induced pruritus during the perioperative period. Canadian Anesthesiologists' Society, 2013 Du Bo-Xiang Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut Song Zhe-Ming Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut Wang Kai Department of Anesthesiology, First Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, PR China aut Zhang Hao Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut Xu Feng-Ying Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut Zou Zui Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut Shi Xue-Yin Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/9(2013-09-01), 907-917 0832-610X 60:9<907 2013 60 12630 https://doi.org/10.1007/s12630-013-9989-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9989-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Du Bo-Xiang Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut NATIONALLICENCE 700 1- Song Zhe-Ming Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut NATIONALLICENCE 700 1- Wang Kai Department of Anesthesiology, First Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, PR China aut NATIONALLICENCE 700 1- Zhang Hao Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut NATIONALLICENCE 700 1- Xu Feng-Ying Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut NATIONALLICENCE 700 1- Zou Zui Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut NATIONALLICENCE 700 1- Shi Xue-Yin Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, PR China aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/9(2013-09-01), 907-917 0832-610X 60:9<907 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer