naa a22 4500 510743218 CHVBK 20180411083035.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12630-013-9954-2 doi (NATIONALLICENCE)springer-10.1007/s12630-013-9954-2 Cerebral oxygen desaturation during one-lung ventilation: correlation with hemodynamic variables [Elektronische Daten] [Ryan Brinkman, Ryan Amadeo, Duane Funk, Linda Girling, Hilary Grocott, W. Mutch] La désaturation cérébrale en oxygène pendant la ventilation sélective: corrélation avec les variables hémodynamiques Purpose: Cerebral desaturation occurs frequently in patients undergoing one-lung ventilation for thoracic surgery. The mechanism of this desaturation is unclear regarding its etiology. The objective of this study was to investigate whether or not decreases in cerebral oxygen saturation associated with one-lung ventilation were a consequence of decreased cardiac output. Methods: A blinded observational study was conducted in 23 patients undergoing one-lung ventilation with thoracic surgery. Eighteen patients completed the study. Cerebral oxygen saturation was monitored using near-infrared spectroscopy (FORE-SIGHT® monitor). Invasive blood pressure was monitored and hemodynamic variables were interrogated using the FloTrac® system. Anesthesia was maintained with sevoflurane with a F i O2 of 1.0. Post-hoc analysis involved a comparison between baseline and integrated changes in cerebral saturation, heart rate, stroke index, cardiac index, and stroke volume variability. Results: All patients showed cerebral desaturation from a baseline of two-lung ventilation in the lateral decubitus position following institution of one-lung ventilation. The cardiac index was stable at these times, but with one-lung ventilation, the heart rate decreased and the stroke index increased to maintain a stable product. The integral of heart rate×time was inversely correlated with the integral of cerebral desaturation×time (linear regression analysis; P=0.02; (df)=16)). Conclusions: Cerebral oxygen desaturation was universal during one-lung ventilation in this study. There was no correlation between cerebral desaturation and cardiac output or other hemodynamic variables. Canadian Anesthesiologists' Society, 2013 Brinkman Ryan Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut Amadeo Ryan Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut Funk Duane Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut Girling Linda Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut Grocott Hilary Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut Mutch W. Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/7(2013-07-01), 660-666 0832-610X 60:7<660 2013 60 12630 https://doi.org/10.1007/s12630-013-9954-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9954-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brinkman Ryan Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Amadeo Ryan Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Funk Duane Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Girling Linda Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Grocott Hilary Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut NATIONALLICENCE 700 1- Mutch W. Department of Anesthesia and Perioperative Medicine, University of Manitoba, 671 William Avenue AE206, Harry Medovy House, R3E 0Z2, Winnipeg, MB, Canada aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/7(2013-07-01), 660-666 0832-610X 60:7<660 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer