naa a22 4500 510743358 CHVBK 20180411083036.0 cr unu---uuuuu 180411e20131201xx s 000 0 eng 10.1007/s12630-013-0043-3 doi (NATIONALLICENCE)springer-10.1007/s12630-013-0043-3 Randomized comparison between the combination of acetaminophen and ibuprofen and each constituent alone for analgesia following tonsillectomy in children [Elektronische Daten] [Alan Merry, Kylie-Ellen Edwards, Zahoor Ahmad, Colin Barber, Murali Mahadevan, Chris Frampton] Comparaison randomisée entre l'association acétaminophène et ibuprofène et chaque molécule seule pour l'analgésie après amygdalectomie chez des enfants Purpose: Combined acetaminophen and ibuprofen may be more effective than either constituent alone for pain in adults. The combination was compared with the individual constituents for analgesia following tonsillectomy in children. Methods: One hundred and fifty-two children (6-14yr) undergoing tonsillectomy were randomized to receive either combination acetaminophen (48mg·kg−1·day−1) and ibuprofen (24mg·kg−1·day−1) or the same doses of acetaminophen alone or ibuprofen alone, every six hours for 48hr. The primary outcome measure was a time-corrected area under the curve (AUCt) calculated from assessments on a 100-mm visual analogue scale (with Wong Baker FACES® as anchors). At each assessment the children rated pain while at rest and on swallowing at multiple time points over the study duration. Secondary outcome measures were a global pain rating, requirement for rescue analgesia, sleep disturbance, and frequency of adverse events. Results: The mean [standard error of the mean (SEM)] AUCt values at rest were; combination 29.6 (1.9), acetaminophen 30.4 (2.0), ibuprofen 34 (1.9). The mean (SEM) AUCt values on swallowing were; combination 39.1 (2.0), acetaminophen 39.9 (2.0), ibuprofen 43.7 (1.9). The mean (95% confidence interval) differences in AUCt values between groups on swallowing were: combination vs acetaminophen −0.9 (−6.2 to 4.5); combination vs ibuprofen −4.6 (−9.9 to 0.67) and at rest were: combination vs acetaminophen −0.81 (−6.11 to 4.48); combination vs ibuprofen −4.37 (−9.62 to 0.88). Differences between groups were not clinically important for the pain scores, similarly for the secondary outcomes. Conclusion: The combination of ibuprofen and acetaminophen was not superior to its individual components in the regimen studied in this pediatric population undergoing tonsillectomy. The study was registered with the Australia New Zealand Clinical Trial Registry (ACTRN12607000005459) on January 4, 2007. Canadian Anesthesiologists' Society, 2013 Merry Alan Department of Anaesthesiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 1142, Auckland, New Zealand aut Edwards Kylie-Ellen Department of Anaesthesiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 1142, Auckland, New Zealand aut Ahmad Zahoor Department of Otolaryngology-Head & Neck Surgery, Counties Manukau District Health Board, Auckland, New Zealand aut Barber Colin Department of Paediatric Otorhinolaryngology, Head and Neck Surgery, Starship Children's Hospital, Auckland, New Zealand aut Mahadevan Murali Department of Paediatric Otorhinolaryngology, Head and Neck Surgery, Starship Children's Hospital, Auckland, New Zealand aut Frampton Chris Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/12(2013-12-01), 1180-1189 0832-610X 60:12<1180 2013 60 12630 https://doi.org/10.1007/s12630-013-0043-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-0043-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merry Alan Department of Anaesthesiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 1142, Auckland, New Zealand aut NATIONALLICENCE 700 1- Edwards Kylie-Ellen Department of Anaesthesiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 1142, Auckland, New Zealand aut NATIONALLICENCE 700 1- Ahmad Zahoor Department of Otolaryngology-Head & Neck Surgery, Counties Manukau District Health Board, Auckland, New Zealand aut NATIONALLICENCE 700 1- Barber Colin Department of Paediatric Otorhinolaryngology, Head and Neck Surgery, Starship Children's Hospital, Auckland, New Zealand aut NATIONALLICENCE 700 1- Mahadevan Murali Department of Paediatric Otorhinolaryngology, Head and Neck Surgery, Starship Children's Hospital, Auckland, New Zealand aut NATIONALLICENCE 700 1- Frampton Chris Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/12(2013-12-01), 1180-1189 0832-610X 60:12<1180 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer