naa a22 4500 510743870 CHVBK 20180411083038.0 cr unu---uuuuu 180411e20131001xx s 000 0 eng 10.1007/s12630-013-0004-x doi (NATIONALLICENCE)springer-10.1007/s12630-013-0004-x Oral and intravenous thyroxine (T4) achieve comparable serum levels for hormonal resuscitation protocol in organ donors: a randomized double-blinded study [Elektronische Daten] [Michael Sharpe, Barbara van Rassel, Wael Haddara] La voie orale permet d'obtenir des taux sériques de thyroxine (T4) comparables à la voie intraveineuse dans le cadre d'un protocole de réanimation hormonale chez les donneurs d'organes: une étude randomisée à double insu Background: Thyroxine (T4) administration is advocated in the management of organ donors; however, the bioavailability of oral thyroxine is unknown in this patient population. Objective: The primary objective of this study was to compare the percentage of the study time (from study drug administration to organ procurement) that patients in the oral vs the intravenous group required inotropic support. Secondary objectives included plasma levels of T3 and T4 and number of organs donated following oral vs intravenous T4 administration. Design: Randomized double-blinded study. Setting: Adult medical-surgical intensive care unit. Patients: Thirty-two adult solid organ donors. Interventions: Patients were randomized to receive either an oral or intravenous dose of T4 (2μg·kg−1). All patients received an oral and intravenous study drug preparation, one of which was a placebo. The study was double-blinded, and randomization occurred in blocks of four and six. Measurements: The number and duration of inotropic/vasopressor therapies and free serum levels of T3 and T4 were determined hourly until procurement. Main results: Following T4 administration, all patients remained on inotropic/vasopressor therapy for the same mean (SD) duration [93 (3)%] of the study period. There was a similar and gradual decrease in the number and dosages of inotropes/vasopressors required in both groups. There was no difference in T3 or T4 levels between groups. Oral bioavailability of T4 was 93% of the intravenous group at six hours and 91% overall. At six hours, the mean area under the curve for T4 was similar between the intravenous group [92.2 (33); 95% confidence interval (CI) 76 to 108.4] and the oral group [86.1 (14); 95% CI 79.4 to 92.8]. Conclusions: Orally administered T4 is well absorbed and achieves a bioavailability of approximately 91-93% of intravenous T4 in organ donors. Inotropic/vasopressor requirements and hemodynamic responses following oral or intravenous thyroxine administration were comparable. Oral T4 is suitable for hormonal therapy for organ donors. This trial was registered at www.clinicaltrials.gov : NCT00238030. Canadian Anesthesiologists' Society, 2013 Sharpe Michael Department of Anesthesia and Perioperative Medicine, London Health Sciences Centre - University Hospital, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Road, N6A 5A5, London, ON, Canada aut van Rassel Barbara Critical Care Western, London Health Sciences Centre - University Hospital, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada aut Haddara Wael Department of Medicine, London Health Sciences Centre - University Hospital, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/10(2013-10-01), 998-1002 0832-610X 60:10<998 2013 60 12630 https://doi.org/10.1007/s12630-013-0004-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-0004-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sharpe Michael Department of Anesthesia and Perioperative Medicine, London Health Sciences Centre - University Hospital, Schulich School of Medicine and Dentistry, Western University, 339 Windermere Road, N6A 5A5, London, ON, Canada aut NATIONALLICENCE 700 1- van Rassel Barbara Critical Care Western, London Health Sciences Centre - University Hospital, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada aut NATIONALLICENCE 700 1- Haddara Wael Department of Medicine, London Health Sciences Centre - University Hospital, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/10(2013-10-01), 998-1002 0832-610X 60:10<998 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer