naa a22 4500 510743897 CHVBK 20180411083038.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12630-013-9896-8 doi (NATIONALLICENCE)springer-10.1007/s12630-013-9896-8 The effects of lidocaine spray and intracuff alkalinized lidocaine on the occurrence of cough at extubation: a double-blind randomized controlled trial [Elektronische Daten] [Frédérick D'Aragon, Nicolas Beaudet, Véronique Gagnon, René Martin, Yanick Sansoucy] Effets de la lidocaïne vaporisée et de la lidocaïne alcalinisée dans le ballonnet sur la survenue de toux au moment de l'extubation: une étude randomisée contrôlée à double insu Purpose: Our study aimed to evaluate the effects of lidocaine sprayed onto the larynx and/or injected into the tracheal tube cuff to decrease the incidence of cough at extubation and postoperative sore throat. Methods: One hundred twenty women scheduled for gynecological surgery<120min in duration were enrolled in this randomized double-blind prospective study. Prior to tracheal intubation, 4% lidocaine or 0.9% saline was sprayed onto the patients' supra- and subglottic areas. After tracheal intubation, the tracheal tube cuff was filled with either an alkalinized 2% lidocaine solution or 0.9% saline. This resulted in four groups: spray-cuff, spray-saline, saline-cuff, and saline-saline. A logistic regression comprising the two factors was used for analysis. The primary outcome was the incidence of cough at extubation. The secondary outcome was the incidence and severity of sore throat reported by patients at 15min, 60min, and 24hr after tracheal extubation. Results: Cough occurred in 42%, 24%, 63%, and 69% of patients in the spray-cuff, spray-saline, saline-cuff, and saline-saline groups, respectively. The use of lidocaine spray decreased the incidence of cough at extubation (odds ratio=0.256; 95% confidence interval 0.118 to 0.554; P<0.001); however, the use of intracuff alkalinized lidocaine had no impact on the occurrence of cough (P=0.471). Severity of sore throat was clinically low (visual analog scale [VAS]≤3) in all groups. No significant difference was observed in hoarseness, dysphagia, nausea, or vomiting. Conclusion: Sprayed lidocaine decreases the incidence of cough at tracheal extubation in surgeries of less than two hours. The use of alkalinized lidocaine into high-volume/low-pressure endotracheal cuffs had no impact on decreasing the incidence of cough or pain. Canadian Anesthesiologists' Society, 2013 D'Aragon Frédérick Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Beaudet Nicolas Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada aut Gagnon Véronique Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Martin René Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Sansoucy Yanick Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/4(2013-04-01), 370-376 0832-610X 60:4<370 2013 60 12630 https://doi.org/10.1007/s12630-013-9896-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9896-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- D'Aragon Frédérick Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Beaudet Nicolas Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Gagnon Véronique Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Martin René Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Sansoucy Yanick Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/4(2013-04-01), 370-376 0832-610X 60:4<370 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer