naa a22 4500 510743927 CHVBK 20180411083038.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12630-013-9885-y doi (NATIONALLICENCE)springer-10.1007/s12630-013-9885-y Preoperative pregabalin does not reduce propofol ED50: a randomized controlled trial [Elektronische Daten] [François Moreau-Bussière, Jonathan Gaulin, Véronique Gagnon, Yanick Sansoucy, Étienne de Médicis] La prégabaline en préopératoire ne réduit pas la DE50 du propofol: une étude randomisée contrôlée Background: In many studies, gabapentinoids, such as pregabalin, have been shown to reduce preoperative anxiety. This anxiolysis is often accompanied by sedation, one of the most frequent side effects of pregabalin. We hypothesized that pregabalin taken preoperatively could reduce propofol requirements for induction of general anesthesia. Methods: A randomized double-blind placebo-controlled trial was conducted after approval by the local ethics committee. Fifty women aged 18-40yr, American Anesthesiologists Society physical status I and II, and scheduled to undergo elective laparoscopic gynecologic procedures were enrolled after written consent. Treatment group patients were given pregabalin 150mg po one hour before surgery while patients in the control group received a placebo. The primary outcome was the propofol dose required to achieve a targeted anesthetic depth in 50% of the population, i.e., effective dose (ED)50. The ED50 was estimated using Dixon's up-and-down methodology. The targeted anesthetic depth was defined based on predetermined entropy monitoring values (State Entropy [SE]<50 and Response Entropy [RE]-SE<10). As a secondary outcome, we tested if pregabalin reduced pre-induction anxiety levels which were measured on a 0-100 scale. Results: The propofol ED50 was not statistically different between the pregabalin group (mean 1.33mg·kg−1; 95% confidence interval [CI] 1.23 to 1.43) vs the placebo group (mean 1.37mg·kg−1; 95% CI 1.28 to 1.46); P=0.19. Also, pre-induction anxiety level was not different between groups (median 31; interquartile range [IQR] [10-52] vs median 42; IQR [4-71], respectively; P=0.41). Conclusions: Preoperative pregabalin does not reduce propofol requirements in a population of healthy young women undergoing laparoscopic gynecologic procedures. This study failed to show a pre-induction anxiolytic effect of pregabalin in such a population. This trial was registered at www.clinicaltrials.gov (NCT01158859). Canadian Anesthesiologists' Society, 2013 Moreau-Bussière François Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Gaulin Jonathan Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Gagnon Véronique Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Sansoucy Yanick Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut de Médicis Étienne Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/4(2013-04-01), 364-369 0832-610X 60:4<364 2013 60 12630 https://doi.org/10.1007/s12630-013-9885-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9885-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moreau-Bussière François Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Gaulin Jonathan Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Gagnon Véronique Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- Sansoucy Yanick Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 700 1- de Médicis Étienne Department of Anesthesiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, J1H 5N4, Sherbrooke, QC, Canada aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/4(2013-04-01), 364-369 0832-610X 60:4<364 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer