naa a22 4500 510743986 CHVBK 20180411083038.0 cr unu---uuuuu 180411e20130401xx s 000 0 eng 10.1007/s12630-013-9886-x doi (NATIONALLICENCE)springer-10.1007/s12630-013-9886-x Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in children [Elektronische Daten] [Jia-Yao Chen, Ji-E. Jia, Ting-Jie Liu, Ming-Ju Qin, Wen-Xian Li] Comparaison des effets de la dexmédétomidine, de la kétamine et d'un placebo sur l'agitation au réveil après une chirurgie du strabisme chez les enfants Background: Children undergoing strabismus surgery under sevoflurane anesthesia often experience emergence agitation (EA) and postoperative vomiting (POV). This study compared the effects of intraoperative dexmedetomidine, ketamine, and placebo on postoperative EA and POV. Methods: Eighty-four children (aged two to seven years) undergoing elective strabismus surgery under sevoflurane anesthesia were randomly assigned to one of three groups (n=28 each). Intraoperatively, the placebo, dexmedetomidine, and ketamine groups received normal saline, dexmedetomidine 1μg·kg−1iv plus a 1 μg·kg−1·hr−1 infusion, and ketamine 1mg·kg−1 iv plus a 1mg·kg−1·hr−1 infusion, respectively. Agitation scores (Pediatric Anesthesia Emergence Delirium [PAED] scale) and POV were assessed in the postanesthetic care unit (PACU) and for 24 hr on the ward. Pain scores and times to laryngeal mask airway (LMA™) removal, resumption of mental orientation, and discharge from the PACU were also assessed. Results: Seventy-eight children completed the study. Peak PAED scores for EA were lower in the dexmedetomidine (P<0.001) and ketamine (P=0.002) groups than in the placebo group. Incidence of POV was lower in the dexmedetomidine group (15%) than in the ketamine (44%; P=0.02) or placebo (45.8%; P=0.02) groups. Pain scores on the ward were lower in the dexmedetomidine (P<0.001) and ketamine (P<0.001) groups than in the placebo group. Time to LMA removal was similar in all groups. Time for resumption of mental orientation and time to discharge from PACU were longer in the dexmedetomidine and ketamine groups than in the placebo group. Conclusions: Dexmedetomidine and ketamine appear to prevent postoperative agitation and pain after sevoflurane anesthesia for pediatric strabismus surgery. Dexmedetomidine also prevents POV. Canadian Anesthesiologists' Society, 2013 Chen Jia-Yao Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut Jia Ji-E Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut Liu Ting-Jie Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut Qin Ming-Ju Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut Li Wen-Xian Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/4(2013-04-01), 385-392 0832-610X 60:4<385 2013 60 12630 https://doi.org/10.1007/s12630-013-9886-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9886-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Jia-Yao Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut NATIONALLICENCE 700 1- Jia Ji-E Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut NATIONALLICENCE 700 1- Liu Ting-Jie Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut NATIONALLICENCE 700 1- Qin Ming-Ju Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut NATIONALLICENCE 700 1- Li Wen-Xian Department of Anesthesiology, EENT Hospital, 200031, Shanghai, China aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/4(2013-04-01), 385-392 0832-610X 60:4<385 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer