naa a22 4500 510744222 CHVBK 20180411083039.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12630-013-9901-2 doi (NATIONALLICENCE)springer-10.1007/s12630-013-9901-2 Insulin/glucose infusion successfully resuscitates bupivacaine-induced sudden-onset circulatory collapse in dogs [Elektronische Daten] [Mi-Hyun Kim, Kook-Hyun Lee, Chong-Soo Kim, Solmon Yang, Teserendorj Uugangerel, Chong-Min Kim, Byeong-Chul Kang] Une perfusion d'insuline et glucose permet la réanimation réussie de chiens après un collapsus circulatoire subit induit par bupivacaïne Purpose: In previous studies, insulin reversed the cardiac toxicity gradually induced by a continuous infusion of bupivacaine. In this randomized controlled study, we intended to simulate a more relevant clinical situation by injecting bupivacaine rapidly as a bolus to induce sudden-onset circulatory collapse in dogs. We then evaluated the insulin effect. Methods: Bupivacaine (10mg·kg−1 iv) was rapidly administered intravenously to 12 dogs. At the onset of circulatory collapse (defined as a mean arterial pressure [MAP] of 30mmHg), external chest compression was initiated. Insulin (2U·kg−1 iv) was given to the insulin-glucose (IG) group (n=6) and the same volume of 0.9% saline was given to the control (C) group (n=6). The primary outcome was successful resuscitation defined as both MAP≥60mmHg and sinus rhythm on an electrocardiogram that lasted≥60sec. Hemodynamic and blood variables were measured, including cardiac output and electrocardiogram intervals. Results: All IG dogs were successfully resuscitated within 15 (3)min, whereas none of the control dogs were resuscitated (P=0.002). After circulatory collapse, the average MAP was higher in group IG than in group C (P=0.006). Conclusion: Insulin effectively reversed the sudden-onset circulatory collapse in dogs caused by an intravenous bolus injection of bupivacaine. Canadian Anesthesiologists' Society, 2013 Kim Mi-Hyun Department of Anesthesiology & Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea aut Lee Kook-Hyun Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut Kim Chong-Soo Department of Anesthesiology & Pain Medicine, Boramae City Hospital, Seoul, South Korea aut Yang Solmon Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut Uugangerel Teserendorj Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut Kim Chong-Min Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut Kang Byeong-Chul Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/5(2013-05-01), 471-478 0832-610X 60:5<471 2013 60 12630 https://doi.org/10.1007/s12630-013-9901-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9901-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Mi-Hyun Department of Anesthesiology & Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea aut NATIONALLICENCE 700 1- Lee Kook-Hyun Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Chong-Soo Department of Anesthesiology & Pain Medicine, Boramae City Hospital, Seoul, South Korea aut NATIONALLICENCE 700 1- Yang Solmon Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Uugangerel Teserendorj Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Chong-Min Department of Anesthesiology & Pain Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Kang Byeong-Chul Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer US; http://www.springer-ny.com 60/5(2013-05-01), 471-478 0832-610X 60:5<471 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer