naa a22 4500 51074432X CHVBK 20180411083040.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12630-013-9902-1 doi (NATIONALLICENCE)springer-10.1007/s12630-013-9902-1 Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: a randomized controlled trial [Elektronische Daten] [James Paul, Manyat Nantha-Aree, Norman Buckley, Ji Cheng, Lehana Thabane, Antonella Tidy, Justin DeBeer, Mitchell Winemaker, David Wismer, Dinshaw Punthakee, Victoria Avram] La gabapentine n'améliore pas l'analgésie multimodale pour l'arthroplastie totale du genou: une étude randomisée contrôlée Purpose: This study assessed whether gabapentin given preoperatively and for two days postoperatively (in addition to patient-controlled analgesia [PCA] morphine, acetaminophen, and ketorolac) is effective in reducing morphine requirements and moderating pain scores when compared with placebo for primary total knee arthroplasty. Methods: This single-centre double-blind randomized controlled trial was undertaken in patients who underwent primary total knee arthroplasty. All subjects received acetaminophen 1,000mg and ketorolac 15mg po preoperatively. Postoperatively, subjects received PCA morphine, acetaminophen 1,000mg every six hours, and ketorolac 15mg po every six hours. Subjects received either gabapentin 600mg po preoperatively followed by 200mg po every eight hours for two days or matching placebo. The primary outcome was cumulative morphine consumption at 72hr following surgery. Secondary outcome measures included pain scores and patient satisfaction. Results: There were 52 subjects in the gabapentin group and 49 subjects in the placebo group. The average cumulative morphine consumption at 72hr postoperatively was 66.3mg in the gabapentin group and 72.5mg in the placebo group (difference −6.2mg; 95% confidence interval −29.1 to 16.8mg; P=0.59). Mean pain scores at rest, with passive movement, or with weight bearing were similar in both groups at corresponding time periods for the first three days following surgery. In addition, mean patient satisfaction scores and hospital length of stay were similar in the two groups. Conclusion: Gabapentin 600mg po given preoperatively followed by 200mg po every eight hours for two days has no effect on postoperative morphine consumption, pain scores, patient satisfaction, or length of hospital stay. This trial is registered at ClinicalTrials.gov NCT01307202. Canadian Anesthesiologists' Society, 2013 Paul James Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut Nantha-Aree Manyat Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut Buckley Norman Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut Cheng Ji Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut Thabane Lehana Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut Tidy Antonella Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut DeBeer Justin Department of Surgery, McMaster University, Hamilton, ON, Canada aut Winemaker Mitchell Department of Surgery, McMaster University, Hamilton, ON, Canada aut Wismer David Department of Surgery, McMaster University, Hamilton, ON, Canada aut Punthakee Dinshaw Department of Surgery, McMaster University, Hamilton, ON, Canada aut Avram Victoria Department of Surgery, McMaster University, Hamilton, ON, Canada aut Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/5(2013-05-01), 423-431 0832-610X 60:5<423 2013 60 12630 https://doi.org/10.1007/s12630-013-9902-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12630-013-9902-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paul James Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Nantha-Aree Manyat Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Buckley Norman Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Cheng Ji Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Thabane Lehana Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Tidy Antonella Department of Anesthesia, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- DeBeer Justin Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Winemaker Mitchell Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Wismer David Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Punthakee Dinshaw Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Avram Victoria Department of Surgery, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 773 0- Canadian Journal of Anesthesia/Journal canadien d'anesthésie Springer-Verlag 60/5(2013-05-01), 423-431 0832-610X 60:5<423 2013 60 12630 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer