naa a22 4500 510745830 CHVBK 20180411083045.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12192-012-0354-2 doi (NATIONALLICENCE)springer-10.1007/s12192-012-0354-2 Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats [Elektronische Daten] [R. Anandan, B. Ganesan, T. Obulesu, S. Mathew, K. Asha, P. Lakshmanan, A. Zynudheen] Aging has been defined as the changes that occur in living organisms with the passage of time that lead to functional impairment and ultimately to death. Free radical-induced oxidative damage has long been thought to be the most important consequence of the aging process. In the present study, an attempt has been made to study the salubrious effects of dietary supplementation of chitosan on glutathione-dependent antioxidant defense system in young and aged rats. The dietary supplementation of chitosan significantly reduced the age-associated dyslipidemic abnormalities noted in the levels of total cholesterol, HDL-cholesterol, and LDL-cholesterol in plasma and heart tissue. Its administration significantly (P < 0.05) attenuated the oxidative stress in the heart tissue of aged rats through the counteraction of free radical formation by maintaining the enzymatic [glutathione peroxidase (GPx) and glutathione reductase (GR)] and non-enzymatic [reduced glutathione (GSH)] status at levels comparable to that of normal young rats. Our results conclude that dietary intake of chitosan restores the depleted myocardial antioxidant status and suggest that it could be an effective therapeutic agent in treatment of age-associated disorders where hypercholesterolemia and oxidative stress are the major causative factors. The Author(s), 2012 Chitosan nationallicence Aging nationallicence Oxidative stress nationallicence Antioxidant status nationallicence Anandan R. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Ganesan B. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Obulesu T. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Mathew S. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Asha K. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Lakshmanan P. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Zynudheen A. Fish Processing Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut Cell Stress and Chaperones Springer Netherlands 18/1(2013-01-01), 121-125 1355-8145 18:1<121 2013 18 12192 https://doi.org/10.1007/s12192-012-0354-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12192-012-0354-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anandan R. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 700 1- Ganesan B. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 700 1- Obulesu T. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 700 1- Mathew S. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 700 1- Asha K. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 700 1- Lakshmanan P. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 700 1- Zynudheen A. Fish Processing Division, Central Institute of Fisheries Technology, Matsyapuri (PO), 682029, Cochin, Kerala, India aut NATIONALLICENCE 773 0- Cell Stress and Chaperones Springer Netherlands 18/1(2013-01-01), 121-125 1355-8145 18:1<121 2013 18 12192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer