naa a22 4500 510745857 CHVBK 20180411083045.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12192-012-0358-y doi (NATIONALLICENCE)springer-10.1007/s12192-012-0358-y Changes in anti-heat shock protein 27 antibody and C-reactive protein levels following cardiac surgery and their association with cardiac function in patients with cardiovascular disease [Elektronische Daten] [Amir Rahsepar, Asadollah Mirzaee, Fatemeh Moodi, Mohsen Moohebati, Shima Tavallaie, Fatemeh Khorashadizadeh, Ali Eshraghi, Maryam-Sadat Alavi, Laya Zarrabi, Mostafa Sajjadian, Maral Amini, Roshanak Khojasteh, Roghayeh Paydar, Somayeh Mousavi, Majid Ghayour-Mobarhan, Gordon Ferns] The relationship between serum anti-heat shock protein (Hsp)27 antibody and high sensitive C-reactive protein (hs-CRP) levels and indices of cardiac function were investigated in patients undergoing coronary artery bypass grafting (CABG) or heart valve replacement. The changes in anti-Hsp27 antibody titers and hs-CRP levels were compared among patients undergoing off-pump and on-pump CABG or valvular heart replacement. Fifty-three patients underwent off-pump, on-pump CABG, and heart valvular replacement in each group. Serum anti-Hsp27 titers and hs-CRP values were measured 24h before and after the operation and at discharge. Echocardiography was performed before surgery and before discharge. The results were compared with values from 83 healthy controls. hs-CRP levels increased and anti-Hsp27 antibody decreased following surgery (P < 0.001 and P < 0.05, respectively), although these changes were independent of operative procedure (P = 0.361 and P = 0.120, respectively). Anti-Hsp27 antibody levels were higher at the time of discharge (P = 0.016). Only in coronary patients were anti-Hsp27 antibody levels negatively associated with E/E′ (r = −0.268, P = 0.022), a marker of pulmonary capillary wedge pressure. In conclusions, anti-Hsp27 antibody levels are associated with indices of cardiac function in coronary patients. Cardiopulmonary bypass had no significant effect on the induction of changes in anti-Hsp27 levels. Moreover, anti-Hsp27 antibody levels fell in all groups postoperatively; this may be due to the formation of immune complexes of antigen-antibody, and antibody levels were higher at the time of discharge. Cell Stress Society International, 2012 Heat shock protein 27 nationallicence Valvular heart disease nationallicence Coronary artery bypass grafting nationallicence Cardiac function nationallicence Rahsepar Amir Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Mirzaee Asadollah Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Moodi Fatemeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Moohebati Mohsen Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Tavallaie Shima Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Khorashadizadeh Fatemeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Eshraghi Ali Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Alavi Maryam-Sadat Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Zarrabi Laya Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Sajjadian Mostafa Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Amini Maral Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Khojasteh Roshanak Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Paydar Roghayeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Mousavi Somayeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Ghayour-Mobarhan Majid Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut Ferns Gordon Institute for Science & Technology in Medicine, Thornburrow Drive, University of Keele, ST4 7QB, Stoke on Trent, Staffordshire, UK aut Cell Stress and Chaperones Springer Netherlands 18/1(2013-01-01), 65-74 1355-8145 18:1<65 2013 18 12192 https://doi.org/10.1007/s12192-012-0358-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12192-012-0358-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rahsepar Amir Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Mirzaee Asadollah Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Moodi Fatemeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Moohebati Mohsen Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Tavallaie Shima Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Khorashadizadeh Fatemeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Eshraghi Ali Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Alavi Maryam-Sadat Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Zarrabi Laya Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Sajjadian Mostafa Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Amini Maral Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Khojasteh Roshanak Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Paydar Roghayeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Mousavi Somayeh Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Ghayour-Mobarhan Majid Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran aut NATIONALLICENCE 700 1- Ferns Gordon Institute for Science & Technology in Medicine, Thornburrow Drive, University of Keele, ST4 7QB, Stoke on Trent, Staffordshire, UK aut NATIONALLICENCE 773 0- Cell Stress and Chaperones Springer Netherlands 18/1(2013-01-01), 65-74 1355-8145 18:1<65 2013 18 12192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer