naa a22 4500 51074589X CHVBK 20180411083046.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12192-013-0425-z doi (NATIONALLICENCE)springer-10.1007/s12192-013-0425-z Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure [Elektronische Daten] [Zsigmond Jenei, Tímea Gombos, Zsolt Förhécz, Zoltán Pozsonyi, István Karádi, Lívia Jánoskuti, Zoltán Prohászka] Predicting the survival of a patient with heart failure (HF) is a complex problem in clinical practice. Our previous study reported that extracellular HSP70 (HSPA1A) correlates with markers of heart function and disease severity in HF, but the predictive value of HSP70 is unclear. The goal of this study was to analyze extracellular HSP70 as predictive marker of mortality in HF. One hundred ninety-five patients with systolic heart failure were enrolled and followed up for 60months. By the end of follow-up, 85 patients were alive (survivors) and 110 died (nonsurvivors). HSP70 (measured by ELISA in the serum) was elevated in nonsurvivors, compared with survivors (0.39 [0.27-0.59] vs. 0.30 [0.24-0.43] ng/ml, respectively, p = 0.0101). In Kaplan-Meier survival analysis higher HSP70 levels above median were associated with a significantly increased mortality. In multivariable survival models, we show that HSP70 level above the median is an age-, sex-, body mass index-, creatinine-, and NT-proBNP-independent predictor of 5-year mortality in HF. Extracellular HSP70 could prove useful for estimating survival in patients with HF. Cell Stress Society International, 2013 HSP70 nationallicence HSPA1A nationallicence Heart failure nationallicence Inflammation nationallicence Prognostic marker nationallicence Five-year survival nationallicence Jenei Zsigmond Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Gombos Tímea Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Förhécz Zsolt Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Pozsonyi Zoltán Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Karádi István Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Jánoskuti Lívia Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Prohászka Zoltán Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut Cell Stress and Chaperones Springer Netherlands 18/6(2013-11-01), 809-813 1355-8145 18:6<809 2013 18 12192 https://doi.org/10.1007/s12192-013-0425-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12192-013-0425-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jenei Zsigmond Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Gombos Tímea Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Förhécz Zsolt Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Pozsonyi Zoltán Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Karádi István Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Jánoskuti Lívia Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 700 1- Prohászka Zoltán Third Department of Internal Medicine, Semmelweis University, Kútvölgyi út 4, 1125, Budapest, Hungary aut NATIONALLICENCE 773 0- Cell Stress and Chaperones Springer Netherlands 18/6(2013-11-01), 809-813 1355-8145 18:6<809 2013 18 12192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer