naa a22 4500 510745946 CHVBK 20180411083046.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12192-013-0420-4 doi (NATIONALLICENCE)springer-10.1007/s12192-013-0420-4 Genetic polymorphisms of HSP70 in age-related cataract [Elektronische Daten] [Yi Zhang, JianYing Gong, Lan Zhang, DaXi Xue, HanRuo Liu, Ping Liu] Polymorphisms have been identified in several HSP70 genes, which may affect HSP70 repair efficiency. We investigated the association of the polymorphisms in HSPA1A, HSPA1B, and HSPA1L genes in the HSPs repair pathway with the risk of cataract in a Chinese population. The study included 415 cataract patients and 386 controls. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. HSPA1B 1267 A/A genotype seems to have a protective role against cataract (p = 0.014, odds ratio (OR) = 0.664, 95% confidence intervals (CI) = 0.480-0.919), and the G allele (p = 0.057, OR = 1.216, 95% CI = 0.999-1.479) does not seem to have a deleterious role in the development of cataract. Haplotypes with frequencies of GAT were significantly different than those of controls (p = 0.005). In HSPA1A G190C and HSPA1L T2437C polymorphisms, there were no significant differences in frequencies of the variant homozygous in patients compared to controls. We conclude that the A/A genotype of HSPA1B A1267G polymorphism seem to have a protective role against age-related cataract. Cell Stress Society International, 2013 Oxidative stress nationallicence Reactive oxygen species nationallicence Polymorphisms nationallicence Cataract nationallicence Heat shock proteins nationallicence Zhang Yi Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut Gong JianYing Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut Zhang Lan Cardiovascular Medicine, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China aut Xue DaXi Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut Liu HanRuo Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut Liu Ping Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut Cell Stress and Chaperones Springer Netherlands 18/6(2013-11-01), 703-709 1355-8145 18:6<703 2013 18 12192 https://doi.org/10.1007/s12192-013-0420-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12192-013-0420-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Yi Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut NATIONALLICENCE 700 1- Gong JianYing Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut NATIONALLICENCE 700 1- Zhang Lan Cardiovascular Medicine, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China aut NATIONALLICENCE 700 1- Xue DaXi Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut NATIONALLICENCE 700 1- Liu HanRuo Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut NATIONALLICENCE 700 1- Liu Ping Eye Hospital, The First Affiliated Hospital, Harbin Medical University, 150001, Harbin, Heilongjiang, China aut NATIONALLICENCE 773 0- Cell Stress and Chaperones Springer Netherlands 18/6(2013-11-01), 703-709 1355-8145 18:6<703 2013 18 12192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer