naa a22 4500 510746136 CHVBK 20180411083046.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12192-013-0401-7 doi (NATIONALLICENCE)springer-10.1007/s12192-013-0401-7 Induction of the 72kDa heat shock protein by glucose ingestion in black pregnant women [Elektronische Daten] [Shirlee Jaffe, Georgios Doulaveris, Theofano Orfanelli, Mariana Arantes, Débora Damasceno, Iracema Calderon, Marilza Rudge, Steven Witkin] Obese Black women are at increased risk for development of gestational diabetes mellitus and have worse perinatal outcomes than do obese women of other ethnicities. Since hsp72 has been associated with the regulation of obesity-induced insulin resistance, we evaluated associations between glucose ingestion, hsp72 release and insulin production in Black pregnant women. Specifically, the effect of a 50-g glucose challenge test (GCT) on heat shock protein and insulin levels in the circulation 1h later was evaluated. Hsp27 and hsp60 levels remained unchanged. In contrast, serum levels of hsp72 markedly increased after glucose ingestion (p = 0.0054). Further analysis revealed that this increase was limited to women who were not obese (body mass index <30). Insulin levels pre-GCT were positively correlated with body mass index (p = 0.0189). Median insulin concentrations also increased post GCT in non-obese women but remained almost unchanged in obese women. Post-GCT serum hsp72 concentrations were inversely correlated with post GCT insulin concentrations (p = 0.0111). These observations suggest that glucose intake during gestation in Black women rapidly leads to an elevation in circulating hsp72 only in non-obese Black women. The release of hsp72 may regulate the extent of insulin production in response to a glucose challenge and, thereby, protect the mother and/or fetus from development of hyperglycemia, hyperinsulinemia, and/or immune system alterations. Cell Stress Society International, 2013 Pregnancy nationallicence Glucose ingestion nationallicence hsp72 nationallicence Black race nationallicence Body mass index nationallicence Insulin nationallicence Jaffe Shirlee Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut Doulaveris Georgios Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut Orfanelli Theofano Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut Arantes Mariana Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut Damasceno Débora Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut Calderon Iracema Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut Rudge Marilza Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut Witkin Steven Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut Cell Stress and Chaperones Springer Netherlands 18/4(2013-07-01), 527-530 1355-8145 18:4<527 2013 18 12192 https://doi.org/10.1007/s12192-013-0401-7 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12192-013-0401-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jaffe Shirlee Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut NATIONALLICENCE 700 1- Doulaveris Georgios Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut NATIONALLICENCE 700 1- Orfanelli Theofano Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut NATIONALLICENCE 700 1- Arantes Mariana Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut NATIONALLICENCE 700 1- Damasceno Débora Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut NATIONALLICENCE 700 1- Calderon Iracema Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut NATIONALLICENCE 700 1- Rudge Marilza Department of Obstetrics and Gynecology, Sao Paulo State University (UNESP), Botucatu, Brazil aut NATIONALLICENCE 700 1- Witkin Steven Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA aut NATIONALLICENCE 773 0- Cell Stress and Chaperones Springer Netherlands 18/4(2013-07-01), 527-530 1355-8145 18:4<527 2013 18 12192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer