naa a22 4500 51074639X CHVBK 20180411083047.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12192-012-0377-8 doi (NATIONALLICENCE)springer-10.1007/s12192-012-0377-8 Serum heat shock protein 27 levels in patients with hepatocellular carcinoma [Elektronische Daten] [Gabriella Gruden, Patrizia Carucci, Valentina Lolli, Loretta Cosso, Erika Dellavalle, Emanuela Rolle, Alessandro Cantamessa, Silvia Pinach, Maria Abate, Donata Campra, Franco Brunello, Graziella Bruno, Mario Rizzetto, Paolo Perin] Levels of serum heat shock protein 27 (sHsp27) have been studied in numerous cancer types, but their potential relevance in patients with hepatocellular carcinoma (HCC) is undetermined. Our aim was to compare sHsp27 levels in patients with HCC and HCC-free controls. Specifically, we recruited 71 patients with HCC (80% with early tumour), 80 patients with chronic liver disease (59 with liver cirrhosis and 21 with chronic active hepatitis) and 42 healthy subjects. sHsp27 was measured by immunoenzymatic assay. Results showed that sHsp27 levels were significantly (p < 0.001) higher in patients with HCC than in the other groups, particularly in those with hepatitis C virus (HCV)-related disease. In HCC patients, sHsp27 levels were not associated with prognostic risk factors, such as size/multiplicity of nodules and stage. In logistic regression analysis, performed in patients with liver disease, log-sHsp27 was associated with a significant age-adjusted 2.5-fold increased odds ratio of HCC and with a significant 4.4-fold higher odds ratio of HCC in the subgroup with HCV-related liver disease. In receiver operating characteristic curve analysis, sensitivity and specificity of the best sHsp27 cut-off value (456.5pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73%, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC. Cell Stress Society International, 2012 Heat shock protein 27 nationallicence Hepatocellular carcinoma nationallicence Liver cirrhosis nationallicence Hepatitis C virus nationallicence Gruden Gabriella Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Carucci Patrizia Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut Lolli Valentina Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Cosso Loretta Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Dellavalle Erika Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Rolle Emanuela Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut Cantamessa Alessandro Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut Pinach Silvia Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Abate Maria Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut Campra Donata Department of Surgery, S. Giovanni Battista Molinette Hospital, Turin, Italy aut Brunello Franco Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut Bruno Graziella Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Rizzetto Mario Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Perin Paolo Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut Cell Stress and Chaperones Springer Netherlands 18/2(2013-03-01), 235-241 1355-8145 18:2<235 2013 18 12192 https://doi.org/10.1007/s12192-012-0377-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12192-012-0377-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gruden Gabriella Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Carucci Patrizia Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Lolli Valentina Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Cosso Loretta Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Dellavalle Erika Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Rolle Emanuela Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Cantamessa Alessandro Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Pinach Silvia Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Abate Maria Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Campra Donata Department of Surgery, S. Giovanni Battista Molinette Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Brunello Franco Department of Gastro-Hepatology, S. Giovanni Battista Molinette Hospital, Turin, Italy aut NATIONALLICENCE 700 1- Bruno Graziella Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Rizzetto Mario Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Perin Paolo Department of Medical Science, University of Turin, C/so AM Dogliotti 14, 10126, Turin, Italy aut NATIONALLICENCE 773 0- Cell Stress and Chaperones Springer Netherlands 18/2(2013-03-01), 235-241 1355-8145 18:2<235 2013 18 12192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer